Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Phase Transformation of Superparamagnetic Iron Oxide Nanoparticles via Thermal Annealing: Implications for Hyperthermia Applications
AU - Crippa, Federica
AU - Rodriguez-Lorenzo, Laura
AU - Hua, Xiao
AU - Goris, Bart
AU - Bals, Sara
AU - Garitaonandia, José S.
AU - Balog, Sandor
AU - Burnand, David
AU - Hirt, Ann M.
AU - Haeni, Laetitia
AU - Lattuada, Marco
AU - Rothen-Rutishauser, Barbara
AU - Petri-Fink, Alke
N1 - doi: 10.1021/acsanm.9b00823
PY - 2019/7/26
Y1 - 2019/7/26
N2 - Magnetic hyperthermia has the potential to play an important role in cancer therapy and its efficacy relies on the nanomaterials selected. Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent candidates due to the ability of producing enough heat to kill tumor cells by thermal ablation. However, their heating properties depend strongly on crystalline structure and size, which may not be controlled and tuned during the synthetic process; therefore, a postprocessing is needed. We show how thermal annealing can be simultaneously coupled with ligand exchange to stabilize the SPIONs in polar solvents and to modify their crystal structure, which improves hyperthermia behavior. Using high-resolution transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, vibrating sample magnetometry, and lock-in thermography, we systematically investigate the impact of size and ligand exchange procedure on crystallinity, their magnetism, and heating ability. We describe a valid and simple approach to optimize SPIONs for hyperthermia by carefully controlling the size, colloidal stability, and crystallinity.
AB - Magnetic hyperthermia has the potential to play an important role in cancer therapy and its efficacy relies on the nanomaterials selected. Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent candidates due to the ability of producing enough heat to kill tumor cells by thermal ablation. However, their heating properties depend strongly on crystalline structure and size, which may not be controlled and tuned during the synthetic process; therefore, a postprocessing is needed. We show how thermal annealing can be simultaneously coupled with ligand exchange to stabilize the SPIONs in polar solvents and to modify their crystal structure, which improves hyperthermia behavior. Using high-resolution transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, vibrating sample magnetometry, and lock-in thermography, we systematically investigate the impact of size and ligand exchange procedure on crystallinity, their magnetism, and heating ability. We describe a valid and simple approach to optimize SPIONs for hyperthermia by carefully controlling the size, colloidal stability, and crystallinity.
U2 - 10.1021/acsanm.9b00823
DO - 10.1021/acsanm.9b00823
M3 - Journal article
VL - 2
SP - 4462
EP - 4470
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
IS - 7
ER -