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  • PHAM-D-16-00693_accepted_pure

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  • 044 - Pharm Res - 2017 - NSAIDS

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Photochemically controlled drug dosing from a polymeric scaffold

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Louise Donnelly
  • John George Hardy
  • Sean P. Gorman
  • David S. Jones
  • Nicola J. Irwin
  • Colin P. McCoy
<mark>Journal publication date</mark>07/2017
<mark>Journal</mark>Pharmaceutical Research
Issue number7
Number of pages8
Pages (from-to)1469-1476
Publication StatusPublished
Early online date15/05/17
<mark>Original language</mark>English


To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2-methyoxyethyl acrylate) (pMEA) scaffold.

Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spectroscopy and mass spectrometry following chromatographic purification. Conjugate photolysis was investigated in acetonitrile solution and within the pMEA matrix following exposure to low-power 365 nm irradiation. Photo-liberation of drug from pMEA into phosphate buffered saline was monitored using UV-vis spectroscopy.

The synthetic procedures yielded the desired drug conjugates with full supporting characterisation. Drug regeneration through photolysis of the synthesised conjugates was successful in both acetonitrile solution and within the pMEA scaffold upon UV irradiation. Conjugates were retained within the pMEA scaffold with exclusive drug liberation following irradiation and increased drug dose with increasing exposure. Multi-dosing capacity was demonstrated though the ability of successive irradiation periods to generate further bursts of drug.

This study demonstrates the first application of photochemically controlled drug release from a biomaterial coating and the feasibility of using pMEA as a scaffold for housing the photoactive drug-DMB conjugates.