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Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean

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Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean. / Cusi, Maria Grazia; Gandolfo, Claudia; Gori Savellini, Gianni et al.

In: Biorxiv, 30.07.2018.

Research output: Contribution to Journal/MagazineJournal article

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APA

Cusi, M. G., Gandolfo, C., Gori Savellini, G., Terrosi, C., Sadler, R., & Gatherer, D. (2018). Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean. Biorxiv. https://doi.org/10.1101/380477

Vancouver

Cusi MG, Gandolfo C, Gori Savellini G, Terrosi C, Sadler R, Gatherer D. Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean. Biorxiv. 2018 Jul 30. doi: 10.1101/380477

Author

Cusi, Maria Grazia ; Gandolfo, Claudia ; Gori Savellini, Gianni et al. / Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean. In: Biorxiv. 2018.

Bibtex

@article{ee487f307fb440c89f2573724cf14ba9,
title = "Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean",
abstract = "All available sequences of the three genome segments of Toscana virus with date and location of sampling were analysed using Bayesian phylodynamic methods. We estimate that extant Toscana virus strains had a common ancestor in the late 16th to early 17th century AD, in territories controlled by the Ottoman Empire, giving rise to an ancestral genotype A/B in north Africa and to genotype C in the Balkans. Subsequent spread into western Europe may have occurred during the period of European colonization of north Africa in the 19th and early 20th centuries AD, establishing genotypes A and B in Italy and Spain respectively. Very little positive evolutionary selection pressure is detectable in Toscana virus, suggesting that the virus has become well adapted to its human hosts. There is also no convincing evidence of reassortment between genome segments, despite genotypes A and B now co-circulating in several countries.",
keywords = "Toscana virus, Sandfly fever Naples phlebovirus, SFNV, Phlebovirus, Phenuiviridae, phylodynamics, Bayesian phylogenetics, phylogenetics, Bunyavirales",
author = "Cusi, {Maria Grazia} and Claudia Gandolfo and {Gori Savellini}, Gianni and Chiara Terrosi and Rebecca Sadler and Derek Gatherer",
year = "2018",
month = jul,
day = "30",
doi = "10.1101/380477",
language = "English",
journal = "Biorxiv",
issn = "2692-8205",
publisher = "Cold Spring Harbor Laboratory Press",

}

RIS

TY - JOUR

T1 - Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean

AU - Cusi, Maria Grazia

AU - Gandolfo, Claudia

AU - Gori Savellini, Gianni

AU - Terrosi, Chiara

AU - Sadler, Rebecca

AU - Gatherer, Derek

PY - 2018/7/30

Y1 - 2018/7/30

N2 - All available sequences of the three genome segments of Toscana virus with date and location of sampling were analysed using Bayesian phylodynamic methods. We estimate that extant Toscana virus strains had a common ancestor in the late 16th to early 17th century AD, in territories controlled by the Ottoman Empire, giving rise to an ancestral genotype A/B in north Africa and to genotype C in the Balkans. Subsequent spread into western Europe may have occurred during the period of European colonization of north Africa in the 19th and early 20th centuries AD, establishing genotypes A and B in Italy and Spain respectively. Very little positive evolutionary selection pressure is detectable in Toscana virus, suggesting that the virus has become well adapted to its human hosts. There is also no convincing evidence of reassortment between genome segments, despite genotypes A and B now co-circulating in several countries.

AB - All available sequences of the three genome segments of Toscana virus with date and location of sampling were analysed using Bayesian phylodynamic methods. We estimate that extant Toscana virus strains had a common ancestor in the late 16th to early 17th century AD, in territories controlled by the Ottoman Empire, giving rise to an ancestral genotype A/B in north Africa and to genotype C in the Balkans. Subsequent spread into western Europe may have occurred during the period of European colonization of north Africa in the 19th and early 20th centuries AD, establishing genotypes A and B in Italy and Spain respectively. Very little positive evolutionary selection pressure is detectable in Toscana virus, suggesting that the virus has become well adapted to its human hosts. There is also no convincing evidence of reassortment between genome segments, despite genotypes A and B now co-circulating in several countries.

KW - Toscana virus

KW - Sandfly fever Naples phlebovirus

KW - SFNV

KW - Phlebovirus

KW - Phenuiviridae

KW - phylodynamics

KW - Bayesian phylogenetics

KW - phylogenetics

KW - Bunyavirales

U2 - 10.1101/380477

DO - 10.1101/380477

M3 - Journal article

JO - Biorxiv

JF - Biorxiv

SN - 2692-8205

ER -