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Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. / Evans, David; Jackman, L. E.; Chamberlain, J. et al.
In: Circulation, Vol. 119, No. 1, 2009, p. 116-122.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Evans, D, Jackman, LE, Chamberlain, J, Crosdale, DJ, Judge, HM, Jetha, K, Norman, KE, Francis, SE & Storey, RF 2009, 'Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis', Circulation, vol. 119, no. 1, pp. 116-122. https://doi.org/10.1161/CIRCULATIONAHA.107.762690

APA

Evans, D., Jackman, L. E., Chamberlain, J., Crosdale, D. J., Judge, H. M., Jetha, K., Norman, K. E., Francis, S. E., & Storey, R. F. (2009). Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. Circulation, 119(1), 116-122. https://doi.org/10.1161/CIRCULATIONAHA.107.762690

Vancouver

Evans D, Jackman LE, Chamberlain J, Crosdale DJ, Judge HM, Jetha K et al. Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. Circulation. 2009;119(1):116-122. Epub 2008 Dec 22. doi: 10.1161/CIRCULATIONAHA.107.762690

Author

Evans, David ; Jackman, L. E. ; Chamberlain, J. et al. / Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. In: Circulation. 2009 ; Vol. 119, No. 1. pp. 116-122.

Bibtex

@article{120a6c471a38436fbd4ad9a8076d92e3,
title = "Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis",
abstract = "Background— Platelets are believed to play an important role in atherogenesis and the vessel response to vascular injury. The P2Y12 receptor (P2Y12) plays a central role in amplifying platelet aggregation, dense granule and α-granule secretion, P-selectin expression, microparticle formation, and procoagulant membrane changes, regardless of the activating stimulus. We hypothesized that P2Y12 deficiency might reduce the vessel wall response to vascular injury as well as thrombosis in murine vascular injury models. Methods and Results— P2Y12-deficient (−/−) mice and littermate controls (+/+) were bred on a C57 BL/6 background. In vivo murine models of arterial injury were employed alone and in combination with bone marrow transplantation to investigate the role of P2Y12 in the vessel wall response to arterial injury and thrombosis. At 21 days after ferric chloride injury, neointima formation in P2Y12−/− arteries was significantly less than that observed in control strain arteries (P<0.025). In agreement with this, the intima-media ratio was significantly greater in femoral wire-injured arteries from P2Y12+/+ compared with P2Y12−/− animals (P<0.05). Bone marrow transplantation was used to examine the importance of vessel wall P2Y12 versus platelet P2Y12. Analysis of arterial sections from chimeric animals at 21 days after injury revealed a smaller intima-media ratio in −/− to +/+ animals than in the positive (+/+ to +/+) control group (P<0.01). Conclusions— These data demonstrate a role for platelet P2Y12 in the vessel wall response to arterial injury and thrombosis. This illustrates the manner in which platelets may contribute to atherogenesis and restenosis.",
keywords = "arterial thrombosis, platelets, restenosis, muscle, smooth",
author = "David Evans and Jackman, {L. E.} and J. Chamberlain and Crosdale, {D. J.} and Judge, {H. M.} and K. Jetha and Norman, {K. E.} and Francis, {S. E.} and Storey, {R. F.}",
year = "2009",
doi = "10.1161/CIRCULATIONAHA.107.762690",
language = "English",
volume = "119",
pages = "116--122",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis

AU - Evans, David

AU - Jackman, L. E.

AU - Chamberlain, J.

AU - Crosdale, D. J.

AU - Judge, H. M.

AU - Jetha, K.

AU - Norman, K. E.

AU - Francis, S. E.

AU - Storey, R. F.

PY - 2009

Y1 - 2009

N2 - Background— Platelets are believed to play an important role in atherogenesis and the vessel response to vascular injury. The P2Y12 receptor (P2Y12) plays a central role in amplifying platelet aggregation, dense granule and α-granule secretion, P-selectin expression, microparticle formation, and procoagulant membrane changes, regardless of the activating stimulus. We hypothesized that P2Y12 deficiency might reduce the vessel wall response to vascular injury as well as thrombosis in murine vascular injury models. Methods and Results— P2Y12-deficient (−/−) mice and littermate controls (+/+) were bred on a C57 BL/6 background. In vivo murine models of arterial injury were employed alone and in combination with bone marrow transplantation to investigate the role of P2Y12 in the vessel wall response to arterial injury and thrombosis. At 21 days after ferric chloride injury, neointima formation in P2Y12−/− arteries was significantly less than that observed in control strain arteries (P<0.025). In agreement with this, the intima-media ratio was significantly greater in femoral wire-injured arteries from P2Y12+/+ compared with P2Y12−/− animals (P<0.05). Bone marrow transplantation was used to examine the importance of vessel wall P2Y12 versus platelet P2Y12. Analysis of arterial sections from chimeric animals at 21 days after injury revealed a smaller intima-media ratio in −/− to +/+ animals than in the positive (+/+ to +/+) control group (P<0.01). Conclusions— These data demonstrate a role for platelet P2Y12 in the vessel wall response to arterial injury and thrombosis. This illustrates the manner in which platelets may contribute to atherogenesis and restenosis.

AB - Background— Platelets are believed to play an important role in atherogenesis and the vessel response to vascular injury. The P2Y12 receptor (P2Y12) plays a central role in amplifying platelet aggregation, dense granule and α-granule secretion, P-selectin expression, microparticle formation, and procoagulant membrane changes, regardless of the activating stimulus. We hypothesized that P2Y12 deficiency might reduce the vessel wall response to vascular injury as well as thrombosis in murine vascular injury models. Methods and Results— P2Y12-deficient (−/−) mice and littermate controls (+/+) were bred on a C57 BL/6 background. In vivo murine models of arterial injury were employed alone and in combination with bone marrow transplantation to investigate the role of P2Y12 in the vessel wall response to arterial injury and thrombosis. At 21 days after ferric chloride injury, neointima formation in P2Y12−/− arteries was significantly less than that observed in control strain arteries (P<0.025). In agreement with this, the intima-media ratio was significantly greater in femoral wire-injured arteries from P2Y12+/+ compared with P2Y12−/− animals (P<0.05). Bone marrow transplantation was used to examine the importance of vessel wall P2Y12 versus platelet P2Y12. Analysis of arterial sections from chimeric animals at 21 days after injury revealed a smaller intima-media ratio in −/− to +/+ animals than in the positive (+/+ to +/+) control group (P<0.01). Conclusions— These data demonstrate a role for platelet P2Y12 in the vessel wall response to arterial injury and thrombosis. This illustrates the manner in which platelets may contribute to atherogenesis and restenosis.

KW - arterial thrombosis

KW - platelets

KW - restenosis

KW - muscle, smooth

U2 - 10.1161/CIRCULATIONAHA.107.762690

DO - 10.1161/CIRCULATIONAHA.107.762690

M3 - Journal article

VL - 119

SP - 116

EP - 122

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 1

ER -