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Platinum catalysed hydrosilylation of propargylic alcohols

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Platinum catalysed hydrosilylation of propargylic alcohols. / McAdam, C.A.; McLaughlin, M.G.; Johnston, A.J.S. et al.
In: Organic and Biomolecular Chemistry, Vol. 11, No. 27, 21.07.2013, p. 4488-4502.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

McAdam, CA, McLaughlin, MG, Johnston, AJS, Chen, J, Walter, MW & Cook, MJ 2013, 'Platinum catalysed hydrosilylation of propargylic alcohols', Organic and Biomolecular Chemistry, vol. 11, no. 27, pp. 4488-4502. https://doi.org/10.1039/c3ob40496j

APA

McAdam, C. A., McLaughlin, M. G., Johnston, A. J. S., Chen, J., Walter, M. W., & Cook, M. J. (2013). Platinum catalysed hydrosilylation of propargylic alcohols. Organic and Biomolecular Chemistry, 11(27), 4488-4502. https://doi.org/10.1039/c3ob40496j

Vancouver

McAdam CA, McLaughlin MG, Johnston AJS, Chen J, Walter MW, Cook MJ. Platinum catalysed hydrosilylation of propargylic alcohols. Organic and Biomolecular Chemistry. 2013 Jul 21;11(27):4488-4502. Epub 2013 May 10. doi: 10.1039/c3ob40496j

Author

McAdam, C.A. ; McLaughlin, M.G. ; Johnston, A.J.S. et al. / Platinum catalysed hydrosilylation of propargylic alcohols. In: Organic and Biomolecular Chemistry. 2013 ; Vol. 11, No. 27. pp. 4488-4502.

Bibtex

@article{11b9980dbc5244c2a9b6d32919481930,
title = "Platinum catalysed hydrosilylation of propargylic alcohols",
abstract = "A facile and user-friendly protocol has been developed for the selective synthesis of E-vinyl silanes derived from propargylic alcohols using a PtCl2/XPhos catalyst system. The reaction is generally high yielding and provides a single regioisomer at the β-position with E-alkene geometry. The reaction is extremely tolerant of functionality and has a wide scope of reactivity both in terms of alkynes and silanes used. The catalyst loading has been investigated and it is found that good reactivity is observed at extremely low catalyst loadings. This methodology has also been extended to a one-pot hydrosilylation Denmark–Hiyama coupling.",
author = "C.A. McAdam and M.G. McLaughlin and A.J.S. Johnston and J. Chen and M.W. Walter and M.J. Cook",
year = "2013",
month = jul,
day = "21",
doi = "10.1039/c3ob40496j",
language = "English",
volume = "11",
pages = "4488--4502",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "27",

}

RIS

TY - JOUR

T1 - Platinum catalysed hydrosilylation of propargylic alcohols

AU - McAdam, C.A.

AU - McLaughlin, M.G.

AU - Johnston, A.J.S.

AU - Chen, J.

AU - Walter, M.W.

AU - Cook, M.J.

PY - 2013/7/21

Y1 - 2013/7/21

N2 - A facile and user-friendly protocol has been developed for the selective synthesis of E-vinyl silanes derived from propargylic alcohols using a PtCl2/XPhos catalyst system. The reaction is generally high yielding and provides a single regioisomer at the β-position with E-alkene geometry. The reaction is extremely tolerant of functionality and has a wide scope of reactivity both in terms of alkynes and silanes used. The catalyst loading has been investigated and it is found that good reactivity is observed at extremely low catalyst loadings. This methodology has also been extended to a one-pot hydrosilylation Denmark–Hiyama coupling.

AB - A facile and user-friendly protocol has been developed for the selective synthesis of E-vinyl silanes derived from propargylic alcohols using a PtCl2/XPhos catalyst system. The reaction is generally high yielding and provides a single regioisomer at the β-position with E-alkene geometry. The reaction is extremely tolerant of functionality and has a wide scope of reactivity both in terms of alkynes and silanes used. The catalyst loading has been investigated and it is found that good reactivity is observed at extremely low catalyst loadings. This methodology has also been extended to a one-pot hydrosilylation Denmark–Hiyama coupling.

U2 - 10.1039/c3ob40496j

DO - 10.1039/c3ob40496j

M3 - Journal article

VL - 11

SP - 4488

EP - 4502

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 27

ER -