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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release. / Sharma, Manoj B.; Abdelmohsen, Hend A. M.; Kap, Özlem et al.
In: Bioengineering, Vol. 11, No. 7, 649, 25.06.2024.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Sharma, MB, Abdelmohsen, HAM, Kap, Ö, Kilic, V, Horzum, N, Cheneler, D & Hardy, JG 2024, 'Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release', Bioengineering, vol. 11, no. 7, 649. https://doi.org/10.3390/bioengineering11070649

APA

Sharma, M. B., Abdelmohsen, H. A. M., Kap, Ö., Kilic, V., Horzum, N., Cheneler, D., & Hardy, J. G. (2024). Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release. Bioengineering, 11(7), Article 649. https://doi.org/10.3390/bioengineering11070649

Vancouver

Sharma MB, Abdelmohsen HAM, Kap Ö, Kilic V, Horzum N, Cheneler D et al. Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release. Bioengineering. 2024 Jun 25;11(7):649. doi: 10.3390/bioengineering11070649

Author

Sharma, Manoj B. ; Abdelmohsen, Hend A. M. ; Kap, Özlem et al. / Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release. In: Bioengineering. 2024 ; Vol. 11, No. 7.

Bibtex

@article{6cde7b30b72144d0a7b637d82235ee0d,
title = "Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release",
abstract = "Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.",
author = "Sharma, {Manoj B.} and Abdelmohsen, {Hend A. M.} and {\"O}zlem Kap and Volkan Kilic and Nesrin Horzum and David Cheneler and Hardy, {John G.}",
year = "2024",
month = jun,
day = "25",
doi = "10.3390/bioengineering11070649",
language = "English",
volume = "11",
journal = "Bioengineering",
issn = "2306-5354",
publisher = "MDPI AG",
number = "7",

}

RIS

TY - JOUR

T1 - Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release

AU - Sharma, Manoj B.

AU - Abdelmohsen, Hend A. M.

AU - Kap, Özlem

AU - Kilic, Volkan

AU - Horzum, Nesrin

AU - Cheneler, David

AU - Hardy, John G.

PY - 2024/6/25

Y1 - 2024/6/25

N2 - Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.

AB - Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.

U2 - 10.3390/bioengineering11070649

DO - 10.3390/bioengineering11070649

M3 - Journal article

VL - 11

JO - Bioengineering

JF - Bioengineering

SN - 2306-5354

IS - 7

M1 - 649

ER -