Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Predicting Spatial Variations in Multiple Measures of PM2.5Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada
AU - Ripley, S.
AU - Minet, L.
AU - Zalzal, J.
AU - Godri Pollitt, K.
AU - Gao, D.
AU - Lakey, P.S.J.
AU - Shiraiwa, M.
AU - Maher, B.A.
AU - Hatzopoulou, M.
AU - Weichenthal, S.
PY - 2022/6/7
Y1 - 2022/6/7
N2 - There is growing interest to move beyond fine particle mass concentrations (PM2.5) when evaluating the population health impacts of outdoor air pollution. However, few exposure models are currently available to support such analyses. In this study, we conducted large-scale monitoring campaigns across Montreal and Toronto, Canada during summer 2018 and winter 2019 and developed models to predict spatial variations in (1) the ability of PM2.5 to generate reactive oxygen species in the lung fluid (ROS), (2) PM2.5 oxidative potential based on the depletion of ascorbate (OPAA) and glutathione (OPGSH) in a cell-free assay, and (3) anhysteretic magnetic remanence (XARM) as an indicator of magnetite nanoparticles. We also examined how exposure to PM oxidative capacity metrics (ROS/OP) varied by socioeconomic status within each city. In Montreal, areas with higher material deprivation, indicating lower area-level average household income and employment, were exposed to PM2.5 characterized by higher ROS and OP. This relationship was not observed in Toronto. The developed models will be used in epidemiologic studies to assess the health effects of exposure to PM2.5 and iron-rich magnetic nanoparticles in Toronto and Montreal.
AB - There is growing interest to move beyond fine particle mass concentrations (PM2.5) when evaluating the population health impacts of outdoor air pollution. However, few exposure models are currently available to support such analyses. In this study, we conducted large-scale monitoring campaigns across Montreal and Toronto, Canada during summer 2018 and winter 2019 and developed models to predict spatial variations in (1) the ability of PM2.5 to generate reactive oxygen species in the lung fluid (ROS), (2) PM2.5 oxidative potential based on the depletion of ascorbate (OPAA) and glutathione (OPGSH) in a cell-free assay, and (3) anhysteretic magnetic remanence (XARM) as an indicator of magnetite nanoparticles. We also examined how exposure to PM oxidative capacity metrics (ROS/OP) varied by socioeconomic status within each city. In Montreal, areas with higher material deprivation, indicating lower area-level average household income and employment, were exposed to PM2.5 characterized by higher ROS and OP. This relationship was not observed in Toronto. The developed models will be used in epidemiologic studies to assess the health effects of exposure to PM2.5 and iron-rich magnetic nanoparticles in Toronto and Montreal.
KW - fine particles
KW - land use regression
KW - oxidative potential
KW - oxidative stress
KW - particulate air pollution
KW - Air pollution
KW - Economics
KW - Land use
KW - Magnetite
KW - Nanomagnetics
KW - Particles (particulate matter)
KW - Developed model
KW - Fine particle mass
KW - Fine-particles
KW - Land use regression
KW - Mass concentration
KW - Oxidative potential
KW - Particulate air pollution
KW - PM 2.5
KW - Spatial variations
KW - Toronto
KW - Magnetite nanoparticles
U2 - 10.1021/acs.est.1c05364
DO - 10.1021/acs.est.1c05364
M3 - Journal article
VL - 56
SP - 7256
EP - 7265
JO - Environmental Science and Technology
JF - Environmental Science and Technology
SN - 0013-936X
IS - 11
ER -