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Predictors of outcome in ulcerative colitis

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Predictors of outcome in ulcerative colitis. / Waterman, Matti; Knight, Jo; Dinani, Amreen et al.

In: Inflammatory Bowel Diseases, Vol. 21, No. 9, 09.2015, p. 2097-2105.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Waterman, M, Knight, J, Dinani, A, Xu, W, Stempak, JM, Croitoru, K, Nguyen, GC, Cohen, Z, McLeod, RS, Greenberg, GR, Steinhart, AH & Silverberg, MS 2015, 'Predictors of outcome in ulcerative colitis', Inflammatory Bowel Diseases, vol. 21, no. 9, pp. 2097-2105. https://doi.org/10.1097/MIB.0000000000000466

APA

Waterman, M., Knight, J., Dinani, A., Xu, W., Stempak, J. M., Croitoru, K., Nguyen, G. C., Cohen, Z., McLeod, R. S., Greenberg, G. R., Steinhart, A. H., & Silverberg, M. S. (2015). Predictors of outcome in ulcerative colitis. Inflammatory Bowel Diseases, 21(9), 2097-2105. https://doi.org/10.1097/MIB.0000000000000466

Vancouver

Waterman M, Knight J, Dinani A, Xu W, Stempak JM, Croitoru K et al. Predictors of outcome in ulcerative colitis. Inflammatory Bowel Diseases. 2015 Sep;21(9):2097-2105. doi: 10.1097/MIB.0000000000000466

Author

Waterman, Matti ; Knight, Jo ; Dinani, Amreen et al. / Predictors of outcome in ulcerative colitis. In: Inflammatory Bowel Diseases. 2015 ; Vol. 21, No. 9. pp. 2097-2105.

Bibtex

@article{f161046f7c62471487f40e5851760cec,
title = "Predictors of outcome in ulcerative colitis",
abstract = "BACKGROUND: Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors of poor disease course. The aim of this study was to identify clinical and genetic markers that can predict prognosis.METHODS: Medical records of patients with UC with ≥5 years of follow-up and available DNA and serum were retrospectively assessed. Immunochip was used to genotype loci associated with immune mediated inflammatory disorders (IMIDs), inflammatory bowel diseases, and other single nucleotide polypmorphisms previously associated with disease severity. Serum levels of pANCA, ASCA, CBir1, and OmpC were also evaluated. Requirement for colectomy, medication, and hospitalization were used to group patients into 3 prognostic groups.RESULTS: Six hundred one patients with UC were classified as mild (n = 78), moderate (n = 273), or severe disease (n = 250). Proximal disease location frequencies at diagnosis were 13%, 21%, and 30% for mild, moderate, and severe UC, respectively (P = 0.001). Disease severity was associated with greater proximal extension rates on follow-up (P < 0.0001) and with shorter time to extension (P = 0.03) and to prednisone initiation (P = 0.0004). When comparing severe UC with mild and moderate UC together, diagnosis age >40 and proximal disease location were associated with severe UC (odds ratios = 1.94 and 2.12, respectively). None of the single nucleotide polypmorphisms or serum markers tested was associated with severe UC, proximal disease extension or colectomy.CONCLUSIONS: Older age and proximal disease location at diagnosis, but not genetic and serum markers, were associated with a more severe course. Further work is required to identify biomarkers that will predict outcomes in UC.",
keywords = "Adolescent, Adult, Age Factors, Age of Onset, Aged, Anti-Inflammatory Agents, Antibodies, Antineutrophil Cytoplasmic, Antibodies, Fungal, Biomarkers, Child, Child, Preschool, Colectomy, Colitis, Ulcerative, Disease Progression, Female, Flagellin, Humans, Inflammation Mediators, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Porins, Predictive Value of Tests, Prednisone, Prognosis, Retrospective Studies, Saccharomyces cerevisiae, Young Adult",
author = "Matti Waterman and Jo Knight and Amreen Dinani and Wei Xu and Stempak, {Joanne M.} and Kenneth Croitoru and Nguyen, {Geoffrey C.} and Zane Cohen and McLeod, {Robin S.} and Greenberg, {Gordon R.} and Steinhart, {A. Hillary} and Silverberg, {Mark S.}",
year = "2015",
month = sep,
doi = "10.1097/MIB.0000000000000466",
language = "English",
volume = "21",
pages = "2097--2105",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Predictors of outcome in ulcerative colitis

AU - Waterman, Matti

AU - Knight, Jo

AU - Dinani, Amreen

AU - Xu, Wei

AU - Stempak, Joanne M.

AU - Croitoru, Kenneth

AU - Nguyen, Geoffrey C.

AU - Cohen, Zane

AU - McLeod, Robin S.

AU - Greenberg, Gordon R.

AU - Steinhart, A. Hillary

AU - Silverberg, Mark S.

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors of poor disease course. The aim of this study was to identify clinical and genetic markers that can predict prognosis.METHODS: Medical records of patients with UC with ≥5 years of follow-up and available DNA and serum were retrospectively assessed. Immunochip was used to genotype loci associated with immune mediated inflammatory disorders (IMIDs), inflammatory bowel diseases, and other single nucleotide polypmorphisms previously associated with disease severity. Serum levels of pANCA, ASCA, CBir1, and OmpC were also evaluated. Requirement for colectomy, medication, and hospitalization were used to group patients into 3 prognostic groups.RESULTS: Six hundred one patients with UC were classified as mild (n = 78), moderate (n = 273), or severe disease (n = 250). Proximal disease location frequencies at diagnosis were 13%, 21%, and 30% for mild, moderate, and severe UC, respectively (P = 0.001). Disease severity was associated with greater proximal extension rates on follow-up (P < 0.0001) and with shorter time to extension (P = 0.03) and to prednisone initiation (P = 0.0004). When comparing severe UC with mild and moderate UC together, diagnosis age >40 and proximal disease location were associated with severe UC (odds ratios = 1.94 and 2.12, respectively). None of the single nucleotide polypmorphisms or serum markers tested was associated with severe UC, proximal disease extension or colectomy.CONCLUSIONS: Older age and proximal disease location at diagnosis, but not genetic and serum markers, were associated with a more severe course. Further work is required to identify biomarkers that will predict outcomes in UC.

AB - BACKGROUND: Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors of poor disease course. The aim of this study was to identify clinical and genetic markers that can predict prognosis.METHODS: Medical records of patients with UC with ≥5 years of follow-up and available DNA and serum were retrospectively assessed. Immunochip was used to genotype loci associated with immune mediated inflammatory disorders (IMIDs), inflammatory bowel diseases, and other single nucleotide polypmorphisms previously associated with disease severity. Serum levels of pANCA, ASCA, CBir1, and OmpC were also evaluated. Requirement for colectomy, medication, and hospitalization were used to group patients into 3 prognostic groups.RESULTS: Six hundred one patients with UC were classified as mild (n = 78), moderate (n = 273), or severe disease (n = 250). Proximal disease location frequencies at diagnosis were 13%, 21%, and 30% for mild, moderate, and severe UC, respectively (P = 0.001). Disease severity was associated with greater proximal extension rates on follow-up (P < 0.0001) and with shorter time to extension (P = 0.03) and to prednisone initiation (P = 0.0004). When comparing severe UC with mild and moderate UC together, diagnosis age >40 and proximal disease location were associated with severe UC (odds ratios = 1.94 and 2.12, respectively). None of the single nucleotide polypmorphisms or serum markers tested was associated with severe UC, proximal disease extension or colectomy.CONCLUSIONS: Older age and proximal disease location at diagnosis, but not genetic and serum markers, were associated with a more severe course. Further work is required to identify biomarkers that will predict outcomes in UC.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Age of Onset

KW - Aged

KW - Anti-Inflammatory Agents

KW - Antibodies, Antineutrophil Cytoplasmic

KW - Antibodies, Fungal

KW - Biomarkers

KW - Child

KW - Child, Preschool

KW - Colectomy

KW - Colitis, Ulcerative

KW - Disease Progression

KW - Female

KW - Flagellin

KW - Humans

KW - Inflammation Mediators

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Polymorphism, Single Nucleotide

KW - Porins

KW - Predictive Value of Tests

KW - Prednisone

KW - Prognosis

KW - Retrospective Studies

KW - Saccharomyces cerevisiae

KW - Young Adult

U2 - 10.1097/MIB.0000000000000466

DO - 10.1097/MIB.0000000000000466

M3 - Journal article

C2 - 26177304

VL - 21

SP - 2097

EP - 2105

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 9

ER -