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Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis

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Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis. / Li, Gen; Liu, Wentao; Liang, Luxin et al.
In: Colloids and Surfaces B: Biointerfaces, Vol. 218, 112762, 31.10.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Li, G, Liu, W, Liang, L, Liu, T, Tian, Y & Wu, H 2022, 'Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis', Colloids and Surfaces B: Biointerfaces, vol. 218, 112762. https://doi.org/10.1016/j.colsurfb.2022.112762

APA

Li, G., Liu, W., Liang, L., Liu, T., Tian, Y., & Wu, H. (2022). Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis. Colloids and Surfaces B: Biointerfaces, 218, Article 112762. https://doi.org/10.1016/j.colsurfb.2022.112762

Vancouver

Li G, Liu W, Liang L, Liu T, Tian Y, Wu H. Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis. Colloids and Surfaces B: Biointerfaces. 2022 Oct 31;218:112762. Epub 2022 Aug 19. doi: 10.1016/j.colsurfb.2022.112762

Author

Li, Gen ; Liu, Wentao ; Liang, Luxin et al. / Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis. In: Colloids and Surfaces B: Biointerfaces. 2022 ; Vol. 218.

Bibtex

@article{68fea7c198264c37a3295f23b069d582,
title = "Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis",
abstract = "The development of additive manufacturing technology has made it possible to customize joint implants. However, the fibrous tissue caused by long-term chronic inflammation delays bone regeneration. Moreover, the discovery of micro/nano-structure on the natural bone makes the study of implant surface morphology meaningful. In this study, a Sr-containing nano-structure on micro-structured titanium alloy surface was fabricated to enhanced the anti-inflammatory and osteogenic properties of implants. Ti6Al4V (TC4) alloys with micro-structured surface prepared by additive manufacturing were used as the material base model. Subsequently, spherical SrTiO3 particles were fabricated on the TC4 surfaces by hydrothermal treatment. The anti-inflammatory and osteogenic performance of smooth surface, micro-structured surface, Sr-containing nano-structured surface and Sr-containing micro/nano-structured surface were investigated. In vitro results exhibited that the macrophages cultured on micro/nano-structured surface were polarized to anti-inflammatory M2 phenotype and enhanced the expression of osteogenic growth factors. The Sr-containing micro/nano-structured surface effectively upgraded the proliferation and differentiation of SaOS-2 cells compared with other surfaces. Sr2+ and micro/nano-structure effectively enhanced the anti-inflammatory and osteogenic properties of titanium alloys. This finding suggested that the micro/nano-structured surface doped with bioactive elements is expected to broaden the horizons of biomedical materials. Data availability The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.",
keywords = "Additive manufacturing, Hydrothermal treatment, Micro/nano-structure, Anti-inflammatory properties, Osteogenic properties",
author = "Gen Li and Wentao Liu and Luxin Liang and Tang Liu and Yingtao Tian and Hong Wu",
year = "2022",
month = oct,
day = "31",
doi = "10.1016/j.colsurfb.2022.112762",
language = "English",
volume = "218",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier Science B.V.",

}

RIS

TY - JOUR

T1 - Preparing Sr-containing nano-structures on micro-structured titanium alloy surface fabricated by additively manufacturing to enhance the anti-inflammation and osteogenesis

AU - Li, Gen

AU - Liu, Wentao

AU - Liang, Luxin

AU - Liu, Tang

AU - Tian, Yingtao

AU - Wu, Hong

PY - 2022/10/31

Y1 - 2022/10/31

N2 - The development of additive manufacturing technology has made it possible to customize joint implants. However, the fibrous tissue caused by long-term chronic inflammation delays bone regeneration. Moreover, the discovery of micro/nano-structure on the natural bone makes the study of implant surface morphology meaningful. In this study, a Sr-containing nano-structure on micro-structured titanium alloy surface was fabricated to enhanced the anti-inflammatory and osteogenic properties of implants. Ti6Al4V (TC4) alloys with micro-structured surface prepared by additive manufacturing were used as the material base model. Subsequently, spherical SrTiO3 particles were fabricated on the TC4 surfaces by hydrothermal treatment. The anti-inflammatory and osteogenic performance of smooth surface, micro-structured surface, Sr-containing nano-structured surface and Sr-containing micro/nano-structured surface were investigated. In vitro results exhibited that the macrophages cultured on micro/nano-structured surface were polarized to anti-inflammatory M2 phenotype and enhanced the expression of osteogenic growth factors. The Sr-containing micro/nano-structured surface effectively upgraded the proliferation and differentiation of SaOS-2 cells compared with other surfaces. Sr2+ and micro/nano-structure effectively enhanced the anti-inflammatory and osteogenic properties of titanium alloys. This finding suggested that the micro/nano-structured surface doped with bioactive elements is expected to broaden the horizons of biomedical materials. Data availability The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.

AB - The development of additive manufacturing technology has made it possible to customize joint implants. However, the fibrous tissue caused by long-term chronic inflammation delays bone regeneration. Moreover, the discovery of micro/nano-structure on the natural bone makes the study of implant surface morphology meaningful. In this study, a Sr-containing nano-structure on micro-structured titanium alloy surface was fabricated to enhanced the anti-inflammatory and osteogenic properties of implants. Ti6Al4V (TC4) alloys with micro-structured surface prepared by additive manufacturing were used as the material base model. Subsequently, spherical SrTiO3 particles were fabricated on the TC4 surfaces by hydrothermal treatment. The anti-inflammatory and osteogenic performance of smooth surface, micro-structured surface, Sr-containing nano-structured surface and Sr-containing micro/nano-structured surface were investigated. In vitro results exhibited that the macrophages cultured on micro/nano-structured surface were polarized to anti-inflammatory M2 phenotype and enhanced the expression of osteogenic growth factors. The Sr-containing micro/nano-structured surface effectively upgraded the proliferation and differentiation of SaOS-2 cells compared with other surfaces. Sr2+ and micro/nano-structure effectively enhanced the anti-inflammatory and osteogenic properties of titanium alloys. This finding suggested that the micro/nano-structured surface doped with bioactive elements is expected to broaden the horizons of biomedical materials. Data availability The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.

KW - Additive manufacturing

KW - Hydrothermal treatment

KW - Micro/nano-structure

KW - Anti-inflammatory properties

KW - Osteogenic properties

U2 - 10.1016/j.colsurfb.2022.112762

DO - 10.1016/j.colsurfb.2022.112762

M3 - Journal article

VL - 218

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

M1 - 112762

ER -