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Presenilins: in search of functionality

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • E H Karran
  • D Allsop
  • G Christie
  • J Davis
  • C Gray
  • F Mansfield
  • R V Ward
<mark>Journal publication date</mark>08/1998
<mark>Journal</mark>Biochemical Society Transactions
Issue number3
Number of pages6
Pages (from-to)491-496
Publication StatusPublished
<mark>Original language</mark>English


The discovery of the PS proteins, the complexities of their biochemistry and their potential involvement in signalling pathways and in apoptosis have galvanized research into AD. To date, the aspect of the functionality of the PSs most relevant to the pathology of AD is the effect of PS FAD mutants to increase the proportion of A beta 42 produced from cells. This, coupled to the observation that gamma-secretase cleavage is considerably reduced in neurons derived from PS-1 knockout mice, argues strongly that PS plays a very direct role in the proteolytic processing of APP.