Home > Research > Publications & Outputs > Preventing the Solid Cancer Progression via Rel...

Links

Text available via DOI:

View graph of relations

Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages. / Kaushik, Nagendra Kumar; Kaushik, Neha; Adhikari, Manish et al.
In: Cancers, Vol. 11, No. 842, 842, 18.06.2019.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Kaushik, NK, Kaushik, N, Adhikari, M, Ghimire, B, Linh, NN, Mishra, YK, Lee, S-J & Choi, EH 2019, 'Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages', Cancers, vol. 11, no. 842, 842. https://doi.org/10.3390/cancers11060842

APA

Kaushik, N. K., Kaushik, N., Adhikari, M., Ghimire, B., Linh, N. N., Mishra, Y. K., Lee, S-J., & Choi, E. H. (2019). Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages. Cancers, 11(842), Article 842. https://doi.org/10.3390/cancers11060842

Vancouver

Kaushik NK, Kaushik N, Adhikari M, Ghimire B, Linh NN, Mishra YK et al. Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages. Cancers. 2019 Jun 18;11(842):842. doi: 10.3390/cancers11060842

Author

Kaushik, Nagendra Kumar ; Kaushik, Neha ; Adhikari, Manish et al. / Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages. In: Cancers. 2019 ; Vol. 11, No. 842.

Bibtex

@article{41e3e59d4ebf488093a3f386e4096d4c,
title = "Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages",
abstract = "Non-thermal atmospheric pressure plasma sources operated in ambient environments are known to generate a variety of reactive oxygen and nitrogen species which could be applied for various biomedical applications. Herein, we fabricate a micro-dielectric barrier discharge plasma device by using screen-printing technology and apply it for studying immuno-stimulatory effects. We demonstrate a tumor-suppressive role for plasma-stimulated macrophages in metastatic solid cancers that directly elicit proliferation and are responsible for tumor relapse mediated by mesenchymal shift. Using microarray analysis, we observed that cold plasma stimulates and differentiates monocyte cells into macrophages as demonstrated by expression of several cytokine/chemokine markers. Moreover, plasma treatment stimulates the differentiation of pro-inflammatory (M1) macrophages to a greater extent. These stimulated macrophages favor anti-tumorigenic immune responses against metastasis acquisition and cancer stem cell maintenance in solid cancers in vitro. Differentiation of monocytes into anticancer macrophages could improve the efficacy of plasma treatment, especially in modifying pro-tumor inflammatory microenvironment through effecting highly resistant immunosuppressive tumor cells associated with tumor relapse.",
keywords = "monocyte-macrophage stimulation, cancer inhibition, mesenchymal shift, cancer stem cells",
author = "Kaushik, {Nagendra Kumar} and Neha Kaushik and Manish Adhikari and Bhagirath Ghimire and Linh, {Nguyen Nhat} and Mishra, {Yogendra Kumar} and Su-Jae Lee and Choi, {Eun Ha}",
year = "2019",
month = jun,
day = "18",
doi = "10.3390/cancers11060842",
language = "English",
volume = "11",
journal = "Cancers",
publisher = "MDPI",
number = "842",

}

RIS

TY - JOUR

T1 - Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages

AU - Kaushik, Nagendra Kumar

AU - Kaushik, Neha

AU - Adhikari, Manish

AU - Ghimire, Bhagirath

AU - Linh, Nguyen Nhat

AU - Mishra, Yogendra Kumar

AU - Lee, Su-Jae

AU - Choi, Eun Ha

PY - 2019/6/18

Y1 - 2019/6/18

N2 - Non-thermal atmospheric pressure plasma sources operated in ambient environments are known to generate a variety of reactive oxygen and nitrogen species which could be applied for various biomedical applications. Herein, we fabricate a micro-dielectric barrier discharge plasma device by using screen-printing technology and apply it for studying immuno-stimulatory effects. We demonstrate a tumor-suppressive role for plasma-stimulated macrophages in metastatic solid cancers that directly elicit proliferation and are responsible for tumor relapse mediated by mesenchymal shift. Using microarray analysis, we observed that cold plasma stimulates and differentiates monocyte cells into macrophages as demonstrated by expression of several cytokine/chemokine markers. Moreover, plasma treatment stimulates the differentiation of pro-inflammatory (M1) macrophages to a greater extent. These stimulated macrophages favor anti-tumorigenic immune responses against metastasis acquisition and cancer stem cell maintenance in solid cancers in vitro. Differentiation of monocytes into anticancer macrophages could improve the efficacy of plasma treatment, especially in modifying pro-tumor inflammatory microenvironment through effecting highly resistant immunosuppressive tumor cells associated with tumor relapse.

AB - Non-thermal atmospheric pressure plasma sources operated in ambient environments are known to generate a variety of reactive oxygen and nitrogen species which could be applied for various biomedical applications. Herein, we fabricate a micro-dielectric barrier discharge plasma device by using screen-printing technology and apply it for studying immuno-stimulatory effects. We demonstrate a tumor-suppressive role for plasma-stimulated macrophages in metastatic solid cancers that directly elicit proliferation and are responsible for tumor relapse mediated by mesenchymal shift. Using microarray analysis, we observed that cold plasma stimulates and differentiates monocyte cells into macrophages as demonstrated by expression of several cytokine/chemokine markers. Moreover, plasma treatment stimulates the differentiation of pro-inflammatory (M1) macrophages to a greater extent. These stimulated macrophages favor anti-tumorigenic immune responses against metastasis acquisition and cancer stem cell maintenance in solid cancers in vitro. Differentiation of monocytes into anticancer macrophages could improve the efficacy of plasma treatment, especially in modifying pro-tumor inflammatory microenvironment through effecting highly resistant immunosuppressive tumor cells associated with tumor relapse.

KW - monocyte-macrophage stimulation

KW - cancer inhibition

KW - mesenchymal shift

KW - cancer stem cells

U2 - 10.3390/cancers11060842

DO - 10.3390/cancers11060842

M3 - Journal article

VL - 11

JO - Cancers

JF - Cancers

IS - 842

M1 - 842

ER -