Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.

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Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro. / O’Dea, Kieran P.; McKean, Paul G.; Harris, Alan et al.
In: Molecular and Biochemical Parasitology, Vol. 72, No. 1-2, 06.1995, p. 111-119.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

O’Dea, KP, McKean, PG, Harris, A & Brown, KN 1995, 'Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.', Molecular and Biochemical Parasitology, vol. 72, no. 1-2, pp. 111-119. https://doi.org/10.1016/0166-6851(95)00090-N

APA

O’Dea, K. P., McKean, P. G., Harris, A., & Brown, K. N. (1995). Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro. Molecular and Biochemical Parasitology, 72(1-2), 111-119. https://doi.org/10.1016/0166-6851(95)00090-N

Vancouver

O’Dea KP, McKean PG, Harris A, Brown KN. Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro. Molecular and Biochemical Parasitology. 1995 Jun;72(1-2):111-119. doi: 10.1016/0166-6851(95)00090-N

Author

O’Dea, Kieran P. ; McKean, Paul G. ; Harris, Alan et al. / Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro. In: Molecular and Biochemical Parasitology. 1995 ; Vol. 72, No. 1-2. pp. 111-119.

Bibtex

@article{e8662968fd8446e59844bb3172254250,

title = "Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.",

abstract = "Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.",

keywords = "Plasmodium chabaudi chabaudi, Plasmodium falciparum, Malaria, Merozoite surface protein 1, Processing",

author = "O{\textquoteright}Dea, {Kieran P.} and McKean, {Paul G.} and Alan Harris and Brown, {K. Neil}",

year = "1995",

month = jun,

doi = "10.1016/0166-6851(95)00090-N",

language = "English",

volume = "72",

pages = "111--119",

journal = "Molecular and Biochemical Parasitology",

issn = "0166-6851",

publisher = "Elsevier",

number = "1-2",

}

RIS

TY - JOUR

T1 - Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.

AU - O’Dea, Kieran P.

AU - McKean, Paul G.

AU - Harris, Alan

AU - Brown, K. Neil

PY - 1995/6

Y1 - 1995/6

N2 - Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.

AB - Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.

KW - Plasmodium chabaudi chabaudi

KW - Plasmodium falciparum

KW - Malaria

KW - Merozoite surface protein 1

KW - Processing

U2 - 10.1016/0166-6851(95)00090-N

DO - 10.1016/0166-6851(95)00090-N

M3 - Journal article

VL - 72

SP - 111

EP - 119

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

SN - 0166-6851

IS - 1-2

ER -

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