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Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation.

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Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. / Duncan, Callum; Li, Hong; Dykhuizen, Roelf et al.
In: Comparative Biochemistry and Physiology Part A: Physiology, Vol. 118, No. 4, 12.1997, p. 939-948.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Duncan, C, Li, H, Dykhuizen, R, Frazer, R, Johnston, P, MacKnight, G, Smith, L, Lamza, K, McKenzie, H, Batt, L, Kelly, D, Golden, M, Benjamin, N & Leifert, C 1997, 'Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation.', Comparative Biochemistry and Physiology Part A: Physiology, vol. 118, no. 4, pp. 939-948. https://doi.org/10.1016/S0300-9629(97)00023-6

APA

Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., Kelly, D., Golden, M., Benjamin, N., & Leifert, C. (1997). Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. Comparative Biochemistry and Physiology Part A: Physiology, 118(4), 939-948. https://doi.org/10.1016/S0300-9629(97)00023-6

Vancouver

Duncan C, Li H, Dykhuizen R, Frazer R, Johnston P, MacKnight G et al. Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. Comparative Biochemistry and Physiology Part A: Physiology. 1997 Dec;118(4):939-948. doi: 10.1016/S0300-9629(97)00023-6

Author

Duncan, Callum ; Li, Hong ; Dykhuizen, Roelf et al. / Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. In: Comparative Biochemistry and Physiology Part A: Physiology. 1997 ; Vol. 118, No. 4. pp. 939-948.

Bibtex

@article{0e4e32ea9d5e4153ad787b67608823ae,
title = "Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation.",
abstract = "Over the last 20 years, dietary nitrate has been implicated in the formation of methemoglobin and carcinogenic nitrosamines in humans. This has led to restrictions of nitrate and nitrite levels in food and drinking water. However, there is no epidemiological evidence for an increased risk of gastric and intestinal cancer in population groups with high dietary vegetable or nitrate intake. A reevaluation of our currently very negative perception of dietary nitrates comes from recent research into the metabolism and enterosalivary circulation of nitrate in mammals. These studies showed that nitrate is converted to nitrite in the oral cavity that then “fuels” an important mammalian resistance mechanism against infectious diseases. Moreover, there is now evidence that the conversion of nitrate into oxides of nitrogen prevents the formation carcinogenic nitrosamines.",
keywords = "Diet, gastric cancer, gastroenteritis, methemoglobinemia, nitrate, nitrite, nitric oxide, N-nitroso compounds",
author = "Callum Duncan and Hong Li and Roelf Dykhuizen and Rennie Frazer and Peter Johnston and Gillian MacKnight and Lorna Smith and Kathryn Lamza and Hamish McKenzie and Les Batt and Denise Kelly and Michael Golden and Nigel Benjamin and Carlo Leifert",
year = "1997",
month = dec,
doi = "10.1016/S0300-9629(97)00023-6",
language = "English",
volume = "118",
pages = "939--948",
journal = "Comparative Biochemistry and Physiology Part A: Physiology",
publisher = "Elsevier Science",
number = "4",

}

RIS

TY - JOUR

T1 - Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation.

AU - Duncan, Callum

AU - Li, Hong

AU - Dykhuizen, Roelf

AU - Frazer, Rennie

AU - Johnston, Peter

AU - MacKnight, Gillian

AU - Smith, Lorna

AU - Lamza, Kathryn

AU - McKenzie, Hamish

AU - Batt, Les

AU - Kelly, Denise

AU - Golden, Michael

AU - Benjamin, Nigel

AU - Leifert, Carlo

PY - 1997/12

Y1 - 1997/12

N2 - Over the last 20 years, dietary nitrate has been implicated in the formation of methemoglobin and carcinogenic nitrosamines in humans. This has led to restrictions of nitrate and nitrite levels in food and drinking water. However, there is no epidemiological evidence for an increased risk of gastric and intestinal cancer in population groups with high dietary vegetable or nitrate intake. A reevaluation of our currently very negative perception of dietary nitrates comes from recent research into the metabolism and enterosalivary circulation of nitrate in mammals. These studies showed that nitrate is converted to nitrite in the oral cavity that then “fuels” an important mammalian resistance mechanism against infectious diseases. Moreover, there is now evidence that the conversion of nitrate into oxides of nitrogen prevents the formation carcinogenic nitrosamines.

AB - Over the last 20 years, dietary nitrate has been implicated in the formation of methemoglobin and carcinogenic nitrosamines in humans. This has led to restrictions of nitrate and nitrite levels in food and drinking water. However, there is no epidemiological evidence for an increased risk of gastric and intestinal cancer in population groups with high dietary vegetable or nitrate intake. A reevaluation of our currently very negative perception of dietary nitrates comes from recent research into the metabolism and enterosalivary circulation of nitrate in mammals. These studies showed that nitrate is converted to nitrite in the oral cavity that then “fuels” an important mammalian resistance mechanism against infectious diseases. Moreover, there is now evidence that the conversion of nitrate into oxides of nitrogen prevents the formation carcinogenic nitrosamines.

KW - Diet

KW - gastric cancer

KW - gastroenteritis

KW - methemoglobinemia

KW - nitrate

KW - nitrite

KW - nitric oxide

KW - N-nitroso compounds

U2 - 10.1016/S0300-9629(97)00023-6

DO - 10.1016/S0300-9629(97)00023-6

M3 - Journal article

VL - 118

SP - 939

EP - 948

JO - Comparative Biochemistry and Physiology Part A: Physiology

JF - Comparative Biochemistry and Physiology Part A: Physiology

IS - 4

ER -