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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Psychological interventions for adults with bipolar disorder
T2 - a systematic review and meta-analysis
AU - Oud, Matthijs
AU - Mayo-Wilson, Evan
AU - Braidwood, Ruth
AU - Schulte, Peter
AU - Jones, Steven
AU - Morriss, Richard
AU - Kupka, Ralph
AU - Cuijpers, Pim
AU - Kendall, Tim
N1 - This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org
PY - 2016/3
Y1 - 2016/3
N2 - BackgroundPsychological interventions may be beneficial in bipolar disorder.AimsTo evaluate the efficacy of psychological interventions for adults with bipolar disorder.MethodA systematic review of randomised controlled trials was conducted. Outcomes were meta-analysed using RevMan and confidence assessed using the GRADE method.ResultsWe included 55 trials with 6010 participants. Moderate-quality evidence associated individual psychological interventions with reduced relapses at post-treatment (risk ratio (RR) = 0.66, 95% CI 0.48–0.92) and follow-up (RR = 0.74, 95% CI 0.63–0.87), and collaborative care with a reduction in hospital admissions (RR = 0.68, 95% CI 0.49–0.94). Low-quality evidence associated group interventions with fewer depression relapses at post-treatment and follow-up, and family psychoeducation with reduced symptoms of depression and mania.ConclusionsThere is evidence that psychological interventions are effective for people with bipolar disorder. Much of the evidence was of low or very low quality thereby limiting our conclusions. Further research should identify the most effective (and cost-effective) interventions for each phase of this disorder.
AB - BackgroundPsychological interventions may be beneficial in bipolar disorder.AimsTo evaluate the efficacy of psychological interventions for adults with bipolar disorder.MethodA systematic review of randomised controlled trials was conducted. Outcomes were meta-analysed using RevMan and confidence assessed using the GRADE method.ResultsWe included 55 trials with 6010 participants. Moderate-quality evidence associated individual psychological interventions with reduced relapses at post-treatment (risk ratio (RR) = 0.66, 95% CI 0.48–0.92) and follow-up (RR = 0.74, 95% CI 0.63–0.87), and collaborative care with a reduction in hospital admissions (RR = 0.68, 95% CI 0.49–0.94). Low-quality evidence associated group interventions with fewer depression relapses at post-treatment and follow-up, and family psychoeducation with reduced symptoms of depression and mania.ConclusionsThere is evidence that psychological interventions are effective for people with bipolar disorder. Much of the evidence was of low or very low quality thereby limiting our conclusions. Further research should identify the most effective (and cost-effective) interventions for each phase of this disorder.
U2 - 10.1192/bjp.bp.114.157123
DO - 10.1192/bjp.bp.114.157123
M3 - Journal article
VL - 208
SP - 213
EP - 222
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - 3
ER -