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    Rights statement: This is the author’s version of a work that was accepted for publication in Journal of the American Academy of Child & Adolescent Psychiatry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the American Academy of Child & Adolescent Psychiatry, 56, 4, 2017 DOI: 10.1016/j.jaac.2017.01.016

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Psychotic symptoms in ADHD: an analysis of the MTA database

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Psychotic symptoms in ADHD : an analysis of the MTA database. / Vitiello, Benedetto ; Perez Algorta, Guillermo Daniel; Arnold, L. Eugene et al.

In: Journal of the Amercian Academy of Child and Adolescent Psychiatry, Vol. 56, No. 4, 04.2017, p. 336-343.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Vitiello, B, Perez Algorta, GD, Arnold, LE, Howard, AL, Stehli, A & Molina, BSG 2017, 'Psychotic symptoms in ADHD: an analysis of the MTA database', Journal of the Amercian Academy of Child and Adolescent Psychiatry, vol. 56, no. 4, pp. 336-343. https://doi.org/10.1016/j.jaac.2017.01.016

APA

Vitiello, B., Perez Algorta, G. D., Arnold, L. E., Howard, A. L., Stehli, A., & Molina, B. S. G. (2017). Psychotic symptoms in ADHD: an analysis of the MTA database. Journal of the Amercian Academy of Child and Adolescent Psychiatry, 56(4), 336-343. https://doi.org/10.1016/j.jaac.2017.01.016

Vancouver

Vitiello B, Perez Algorta GD, Arnold LE, Howard AL, Stehli A, Molina BSG. Psychotic symptoms in ADHD: an analysis of the MTA database. Journal of the Amercian Academy of Child and Adolescent Psychiatry. 2017 Apr;56(4):336-343. Epub 2017 Feb 4. doi: 10.1016/j.jaac.2017.01.016

Author

Vitiello, Benedetto ; Perez Algorta, Guillermo Daniel ; Arnold, L. Eugene et al. / Psychotic symptoms in ADHD : an analysis of the MTA database. In: Journal of the Amercian Academy of Child and Adolescent Psychiatry. 2017 ; Vol. 56, No. 4. pp. 336-343.

Bibtex

@article{72afa91fb4f848969eebe5c334057900,
title = "Psychotic symptoms in ADHD: an analysis of the MTA database",
abstract = "Objective: To assess the prevalence of psychotic symptoms among youths (age 14-25 years) with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) combined type. Method: The participants in the Multimodal Treatment Study of Children with ADHD (MTA) and a local normative comparison group (LNCG) were systematically assessed 6, 8, 10, 12, 14, and 16 years after the original enrollment at a mean age of 8.5 years. Trained research assistants administered a psychosis screener, and positive screens were referred to study clinicians to confirm or exclude psychosis. Possible associations between screening positive and alcohol or substance use were assessed. Results: Data were available from 509 MTA participants (88% of the original MTA sample) and 276 LNCG subjects (96% of the original sample), with a mean age of 25.1 and 24.6 years, respectively, at Year 16. Twenty-six MTA subjects (5%, 95% CI: 3, 7) and 11 LNCG (4%, 95% CI: 2, 6) screened positive for at least one psychotic symptom (p=0.60). Most psychotic symptoms were transient. The prevalence of clinician-confirmed psychotic symptoms was 1.1% (95% C.I. 0.2, 2.1) in the MTA and 0.7% (0, 1.7) in the LNCG (p=0.72). Greater cannabis use was reported by those who screened (p<0.05) and were confirmed positive (p<0.01). Conclusions: There was no evidence that ADHD increased the risk for psychotic symptoms. In both the ADHD and normative comparison groups, more frequent cannabis use was associated with greater likelihood of experiencing psychotic symptoms, thus supporting the recommendation that youth should not use cannabis. ",
keywords = "ADHD, adolescents, psychosis, cannabis, screening",
author = "Benedetto Vitiello and {Perez Algorta}, {Guillermo Daniel} and Arnold, {L. Eugene} and Howard, {Andrea L.} and Annamarie Stehli and Molina, {Brooke S.G.}",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Journal of the American Academy of Child & Adolescent Psychiatry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the American Academy of Child & Adolescent Psychiatry, 56, 4, 2017 DOI: 10.1016/j.jaac.2017.01.016",
year = "2017",
month = apr,
doi = "10.1016/j.jaac.2017.01.016",
language = "English",
volume = "56",
pages = "336--343",
journal = "Journal of the Amercian Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "4",

}

RIS

TY - JOUR

T1 - Psychotic symptoms in ADHD

T2 - an analysis of the MTA database

AU - Vitiello, Benedetto

AU - Perez Algorta, Guillermo Daniel

AU - Arnold, L. Eugene

AU - Howard, Andrea L.

AU - Stehli, Annamarie

AU - Molina, Brooke S.G.

N1 - This is the author’s version of a work that was accepted for publication in Journal of the American Academy of Child & Adolescent Psychiatry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the American Academy of Child & Adolescent Psychiatry, 56, 4, 2017 DOI: 10.1016/j.jaac.2017.01.016

PY - 2017/4

Y1 - 2017/4

N2 - Objective: To assess the prevalence of psychotic symptoms among youths (age 14-25 years) with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) combined type. Method: The participants in the Multimodal Treatment Study of Children with ADHD (MTA) and a local normative comparison group (LNCG) were systematically assessed 6, 8, 10, 12, 14, and 16 years after the original enrollment at a mean age of 8.5 years. Trained research assistants administered a psychosis screener, and positive screens were referred to study clinicians to confirm or exclude psychosis. Possible associations between screening positive and alcohol or substance use were assessed. Results: Data were available from 509 MTA participants (88% of the original MTA sample) and 276 LNCG subjects (96% of the original sample), with a mean age of 25.1 and 24.6 years, respectively, at Year 16. Twenty-six MTA subjects (5%, 95% CI: 3, 7) and 11 LNCG (4%, 95% CI: 2, 6) screened positive for at least one psychotic symptom (p=0.60). Most psychotic symptoms were transient. The prevalence of clinician-confirmed psychotic symptoms was 1.1% (95% C.I. 0.2, 2.1) in the MTA and 0.7% (0, 1.7) in the LNCG (p=0.72). Greater cannabis use was reported by those who screened (p<0.05) and were confirmed positive (p<0.01). Conclusions: There was no evidence that ADHD increased the risk for psychotic symptoms. In both the ADHD and normative comparison groups, more frequent cannabis use was associated with greater likelihood of experiencing psychotic symptoms, thus supporting the recommendation that youth should not use cannabis.

AB - Objective: To assess the prevalence of psychotic symptoms among youths (age 14-25 years) with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) combined type. Method: The participants in the Multimodal Treatment Study of Children with ADHD (MTA) and a local normative comparison group (LNCG) were systematically assessed 6, 8, 10, 12, 14, and 16 years after the original enrollment at a mean age of 8.5 years. Trained research assistants administered a psychosis screener, and positive screens were referred to study clinicians to confirm or exclude psychosis. Possible associations between screening positive and alcohol or substance use were assessed. Results: Data were available from 509 MTA participants (88% of the original MTA sample) and 276 LNCG subjects (96% of the original sample), with a mean age of 25.1 and 24.6 years, respectively, at Year 16. Twenty-six MTA subjects (5%, 95% CI: 3, 7) and 11 LNCG (4%, 95% CI: 2, 6) screened positive for at least one psychotic symptom (p=0.60). Most psychotic symptoms were transient. The prevalence of clinician-confirmed psychotic symptoms was 1.1% (95% C.I. 0.2, 2.1) in the MTA and 0.7% (0, 1.7) in the LNCG (p=0.72). Greater cannabis use was reported by those who screened (p<0.05) and were confirmed positive (p<0.01). Conclusions: There was no evidence that ADHD increased the risk for psychotic symptoms. In both the ADHD and normative comparison groups, more frequent cannabis use was associated with greater likelihood of experiencing psychotic symptoms, thus supporting the recommendation that youth should not use cannabis.

KW - ADHD

KW - adolescents

KW - psychosis

KW - cannabis

KW - screening

U2 - 10.1016/j.jaac.2017.01.016

DO - 10.1016/j.jaac.2017.01.016

M3 - Journal article

VL - 56

SP - 336

EP - 343

JO - Journal of the Amercian Academy of Child and Adolescent Psychiatry

JF - Journal of the Amercian Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 4

ER -