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Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation

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Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation. / Lin, Hungyen; Dong, Yue; Shen, Yaochun et al.
In: Journal of Pharmaceutical Sciences, Vol. 104, No. 10, 2015, p. 3377-3385.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lin, H, Dong, Y, Shen, Y & Zeitler, JA 2015, 'Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation', Journal of Pharmaceutical Sciences, vol. 104, no. 10, pp. 3377-3385. https://doi.org/10.1002/jps.24535

APA

Lin, H., Dong, Y., Shen, Y., & Zeitler, J. A. (2015). Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation. Journal of Pharmaceutical Sciences, 104(10), 3377-3385. https://doi.org/10.1002/jps.24535

Vancouver

Lin H, Dong Y, Shen Y, Zeitler JA. Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation. Journal of Pharmaceutical Sciences. 2015;104(10):3377-3385. doi: 10.1002/jps.24535

Author

Lin, Hungyen ; Dong, Yue ; Shen, Yaochun et al. / Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging : an evaluation. In: Journal of Pharmaceutical Sciences. 2015 ; Vol. 104, No. 10. pp. 3377-3385.

Bibtex

@article{4c5bd31bddd24ed3832cb2c2e19a875e,
title = "Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation",
abstract = "Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Because of the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical coating quantification, this paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting. In order to facilitate automated coating quantification for film coating thickness in the range of 30–200 μm, an algorithm that uses wavelet denoising and a tailored peak finding method is proposed to analyse each of the acquired A-scan. Results obtained from running the algorithm reveal an increasing disparity between the TPI and OCT measured intra-tablet variability when film coating thickness exceeds 100 μm. The finding further confirms that OCT is a suitable modality for characterising pharmaceutical dosage forms with thin film coatings, whereas TPI is well suited for thick coatings.",
author = "Hungyen Lin and Yue Dong and Yaochun Shen and Zeitler, {J. Axel}",
year = "2015",
doi = "10.1002/jps.24535",
language = "English",
volume = "104",
pages = "3377--3385",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging

T2 - an evaluation

AU - Lin, Hungyen

AU - Dong, Yue

AU - Shen, Yaochun

AU - Zeitler, J. Axel

PY - 2015

Y1 - 2015

N2 - Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Because of the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical coating quantification, this paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting. In order to facilitate automated coating quantification for film coating thickness in the range of 30–200 μm, an algorithm that uses wavelet denoising and a tailored peak finding method is proposed to analyse each of the acquired A-scan. Results obtained from running the algorithm reveal an increasing disparity between the TPI and OCT measured intra-tablet variability when film coating thickness exceeds 100 μm. The finding further confirms that OCT is a suitable modality for characterising pharmaceutical dosage forms with thin film coatings, whereas TPI is well suited for thick coatings.

AB - Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Because of the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical coating quantification, this paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting. In order to facilitate automated coating quantification for film coating thickness in the range of 30–200 μm, an algorithm that uses wavelet denoising and a tailored peak finding method is proposed to analyse each of the acquired A-scan. Results obtained from running the algorithm reveal an increasing disparity between the TPI and OCT measured intra-tablet variability when film coating thickness exceeds 100 μm. The finding further confirms that OCT is a suitable modality for characterising pharmaceutical dosage forms with thin film coatings, whereas TPI is well suited for thick coatings.

U2 - 10.1002/jps.24535

DO - 10.1002/jps.24535

M3 - Journal article

VL - 104

SP - 3377

EP - 3385

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 10

ER -