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Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease

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Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease. / Gentleman, S M; Allsop, D; Bruton, C J et al.
In: Neuroscience Letters, Vol. 136, No. 1, 17.02.1992, p. 27-30.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gentleman, SM, Allsop, D, Bruton, CJ, Jagoe, R, Polak, JM & Roberts, GW 1992, 'Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease', Neuroscience Letters, vol. 136, no. 1, pp. 27-30. https://doi.org/10.1016/0304-3940(92)90639-O

APA

Gentleman, S. M., Allsop, D., Bruton, C. J., Jagoe, R., Polak, J. M., & Roberts, G. W. (1992). Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease. Neuroscience Letters, 136(1), 27-30. https://doi.org/10.1016/0304-3940(92)90639-O

Vancouver

Gentleman SM, Allsop D, Bruton CJ, Jagoe R, Polak JM, Roberts GW. Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease. Neuroscience Letters. 1992 Feb 17;136(1):27-30. doi: 10.1016/0304-3940(92)90639-O

Author

Gentleman, S M ; Allsop, D ; Bruton, C J et al. / Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease. In: Neuroscience Letters. 1992 ; Vol. 136, No. 1. pp. 27-30.

Bibtex

@article{640b75011dfd468caf715d958af06d86,
title = "Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease",
abstract = "The distribution of beta-amyloid protein (beta A4) in the frontal and temporal isocortex of 14 Alzheimer's disease brains was examined using a combination of immunohistochemistry and computer image analysis. The area of cortex covered by beta A4 deposits was determined and expressed as a percentage of the total cortical grey matter area in each field of interest. Significantly more beta A4 was found in the grey matter of the sulci as compared to that of the gyral crests in both the frontal and the temporal lobes (P less than 0.05). Furthermore, in each case, greater quantities of beta A4 were observed in the frontal rather than the temporal lobes. This apparent differential vulnerability is likely to reflect underlying anatomical connections or perhaps differences in cell packing density and appears to strengthen the case for an anatomical basis for the spread of the disease pathology.",
keywords = "Alzheimer Disease, Amyloid beta-Peptides, Frontal Lobe, Humans, Neurofibrillary Tangles, Temporal Lobe",
author = "Gentleman, {S M} and D Allsop and Bruton, {C J} and R Jagoe and Polak, {J M} and Roberts, {G W}",
year = "1992",
month = feb,
day = "17",
doi = "10.1016/0304-3940(92)90639-O",
language = "English",
volume = "136",
pages = "27--30",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "ELSEVIER IRELAND LTD",
number = "1",

}

RIS

TY - JOUR

T1 - Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease

AU - Gentleman, S M

AU - Allsop, D

AU - Bruton, C J

AU - Jagoe, R

AU - Polak, J M

AU - Roberts, G W

PY - 1992/2/17

Y1 - 1992/2/17

N2 - The distribution of beta-amyloid protein (beta A4) in the frontal and temporal isocortex of 14 Alzheimer's disease brains was examined using a combination of immunohistochemistry and computer image analysis. The area of cortex covered by beta A4 deposits was determined and expressed as a percentage of the total cortical grey matter area in each field of interest. Significantly more beta A4 was found in the grey matter of the sulci as compared to that of the gyral crests in both the frontal and the temporal lobes (P less than 0.05). Furthermore, in each case, greater quantities of beta A4 were observed in the frontal rather than the temporal lobes. This apparent differential vulnerability is likely to reflect underlying anatomical connections or perhaps differences in cell packing density and appears to strengthen the case for an anatomical basis for the spread of the disease pathology.

AB - The distribution of beta-amyloid protein (beta A4) in the frontal and temporal isocortex of 14 Alzheimer's disease brains was examined using a combination of immunohistochemistry and computer image analysis. The area of cortex covered by beta A4 deposits was determined and expressed as a percentage of the total cortical grey matter area in each field of interest. Significantly more beta A4 was found in the grey matter of the sulci as compared to that of the gyral crests in both the frontal and the temporal lobes (P less than 0.05). Furthermore, in each case, greater quantities of beta A4 were observed in the frontal rather than the temporal lobes. This apparent differential vulnerability is likely to reflect underlying anatomical connections or perhaps differences in cell packing density and appears to strengthen the case for an anatomical basis for the spread of the disease pathology.

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Frontal Lobe

KW - Humans

KW - Neurofibrillary Tangles

KW - Temporal Lobe

U2 - 10.1016/0304-3940(92)90639-O

DO - 10.1016/0304-3940(92)90639-O

M3 - Journal article

C2 - 1635663

VL - 136

SP - 27

EP - 30

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -