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Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. / Yorucu, C.; Lau, K.; Mittar, S. et al.
In: APPLIED SPECTROSCOPY REVIEWS, Vol. 51, No. 4, 01.05.2016, p. 263-277 .

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Yorucu, C, Lau, K, Mittar, S, Green, NH, Raza, A, Rehman, IU & MacNeil, S 2016, 'Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models', APPLIED SPECTROSCOPY REVIEWS, vol. 51, no. 4, pp. 263-277 . https://doi.org/10.1080/05704928.2015.1126840

APA

Yorucu, C., Lau, K., Mittar, S., Green, N. H., Raza, A., Rehman, I. U., & MacNeil, S. (2016). Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. APPLIED SPECTROSCOPY REVIEWS, 51(4), 263-277 . https://doi.org/10.1080/05704928.2015.1126840

Vancouver

Yorucu C, Lau K, Mittar S, Green NH, Raza A, Rehman IU et al. Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. APPLIED SPECTROSCOPY REVIEWS. 2016 May 1;51(4):263-277 . doi: 10.1080/05704928.2015.1126840

Author

Yorucu, C. ; Lau, K. ; Mittar, S. et al. / Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models. In: APPLIED SPECTROSCOPY REVIEWS. 2016 ; Vol. 51, No. 4. pp. 263-277 .

Bibtex

@article{78184d3569e0446ca7ba0babfeb7cc16,
title = "Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models",
abstract = "Invasion of melanoma cells from the primary tumor involves interaction with adjacent tissues and extracellular matrix. The extent of this interaction is not fully understood. In this study Raman spectroscopy was applied to cryo-sections of established 3D models of melanoma in human skin. Principal component analysis was used to investigate differences between the tumor and normal tissue and between the peri-tumor area and the normal skin. Two human melanoma cells lines A375SM and C8161 were investigated and compared in 3D melanoma models. Changes were found in protein conformations and tryptophan configurations across the entire melanoma samples, in tyrosine orientation and in more fluid lipid packing only in tumor dense areas, and in increased glycogen content in the peri-tumor areas of melanoma. Raman spectroscopy revealed changes around the perimeter of a melanoma tumor as well as detecting differences between the tumor and the normal tissue. {\textcopyright} 2016 Ceyla Yorucu, Katherine Lau, Shweta Mittar, Nicola H. Green, Ahtasham Raza, Ihtesham Ur Rehman, and Sheila MacNeil.",
keywords = "melanoma, metastases, Raman spectroscopy, tissue engineering, Amino acids, Dermatology, Oncology, Principal component analysis, Tissue engineering, Tumors, Extracellular matrices, Melanoma cells, Melanoma tumors, Normal skin, Normal tissue, Protein conformation, Tissue",
author = "C. Yorucu and K. Lau and S. Mittar and N.H. Green and A. Raza and I.U. Rehman and S. MacNeil",
year = "2016",
month = may,
day = "1",
doi = "10.1080/05704928.2015.1126840",
language = "English",
volume = "51",
pages = "263--277 ",
journal = "APPLIED SPECTROSCOPY REVIEWS",
issn = "0570-4928",
publisher = "Taylor and Francis Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models

AU - Yorucu, C.

AU - Lau, K.

AU - Mittar, S.

AU - Green, N.H.

AU - Raza, A.

AU - Rehman, I.U.

AU - MacNeil, S.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Invasion of melanoma cells from the primary tumor involves interaction with adjacent tissues and extracellular matrix. The extent of this interaction is not fully understood. In this study Raman spectroscopy was applied to cryo-sections of established 3D models of melanoma in human skin. Principal component analysis was used to investigate differences between the tumor and normal tissue and between the peri-tumor area and the normal skin. Two human melanoma cells lines A375SM and C8161 were investigated and compared in 3D melanoma models. Changes were found in protein conformations and tryptophan configurations across the entire melanoma samples, in tyrosine orientation and in more fluid lipid packing only in tumor dense areas, and in increased glycogen content in the peri-tumor areas of melanoma. Raman spectroscopy revealed changes around the perimeter of a melanoma tumor as well as detecting differences between the tumor and the normal tissue. © 2016 Ceyla Yorucu, Katherine Lau, Shweta Mittar, Nicola H. Green, Ahtasham Raza, Ihtesham Ur Rehman, and Sheila MacNeil.

AB - Invasion of melanoma cells from the primary tumor involves interaction with adjacent tissues and extracellular matrix. The extent of this interaction is not fully understood. In this study Raman spectroscopy was applied to cryo-sections of established 3D models of melanoma in human skin. Principal component analysis was used to investigate differences between the tumor and normal tissue and between the peri-tumor area and the normal skin. Two human melanoma cells lines A375SM and C8161 were investigated and compared in 3D melanoma models. Changes were found in protein conformations and tryptophan configurations across the entire melanoma samples, in tyrosine orientation and in more fluid lipid packing only in tumor dense areas, and in increased glycogen content in the peri-tumor areas of melanoma. Raman spectroscopy revealed changes around the perimeter of a melanoma tumor as well as detecting differences between the tumor and the normal tissue. © 2016 Ceyla Yorucu, Katherine Lau, Shweta Mittar, Nicola H. Green, Ahtasham Raza, Ihtesham Ur Rehman, and Sheila MacNeil.

KW - melanoma

KW - metastases

KW - Raman spectroscopy

KW - tissue engineering

KW - Amino acids

KW - Dermatology

KW - Oncology

KW - Principal component analysis

KW - Tissue engineering

KW - Tumors

KW - Extracellular matrices

KW - Melanoma cells

KW - Melanoma tumors

KW - Normal skin

KW - Normal tissue

KW - Protein conformation

KW - Tissue

U2 - 10.1080/05704928.2015.1126840

DO - 10.1080/05704928.2015.1126840

M3 - Journal article

VL - 51

SP - 263

EP - 277

JO - APPLIED SPECTROSCOPY REVIEWS

JF - APPLIED SPECTROSCOPY REVIEWS

SN - 0570-4928

IS - 4

ER -