Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Rapid increase in Omicron infections in England during December 2021 : REACT-1 study. / Elliott, Paul; Bodinier, Barbara; Eales, Oliver et al.
In: Science, Vol. 375, No. 6587, eabn8347, 28.02.2022, p. 1406-1411.Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Rapid increase in Omicron infections in England during December 2021
T2 - REACT-1 study
AU - Elliott, Paul
AU - Bodinier, Barbara
AU - Eales, Oliver
AU - Wang, Haowei
AU - Haw, David
AU - Elliott, Joshua
AU - Whitaker, Matthew
AU - Jonnerby, Jakob
AU - Tang, David
AU - Walters, Caroline E
AU - Atchison, Christina
AU - Diggle, Peter J
AU - Page, Andrew J
AU - Trotter, Alexander J
AU - Ashby, Deborah
AU - Barclay, Wendy
AU - Taylor, Graham
AU - Ward, Helen
AU - Darzi, Ara
AU - Cooke, Graham S
AU - Chadeau-Hyam, Marc
AU - Donnelly, Christl A
PY - 2022/2/28
Y1 - 2022/2/28
N2 - The unprecedented rise in SARS-CoV-2 infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed prevalence of SARS-CoV-2 and its dynamics in England from end November to mid-December 2021 among almost 100,000 participants from the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, and an increasing proportion of infections due to Omicron. We observed large falls in swab positivity among mostly vaccinated older children (12-17 years) compared with unvaccinated younger children (5-11 years), and in adults who received a third (booster) vaccine dose vs. two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.
AB - The unprecedented rise in SARS-CoV-2 infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed prevalence of SARS-CoV-2 and its dynamics in England from end November to mid-December 2021 among almost 100,000 participants from the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, and an increasing proportion of infections due to Omicron. We observed large falls in swab positivity among mostly vaccinated older children (12-17 years) compared with unvaccinated younger children (5-11 years), and in adults who received a third (booster) vaccine dose vs. two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.
U2 - 10.1126/science.abn8347
DO - 10.1126/science.abn8347
M3 - Journal article
C2 - 35133177
VL - 375
SP - 1406
EP - 1411
JO - Science
JF - Science
SN - 0036-8075
IS - 6587
M1 - eabn8347
ER -