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Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. / Mort, Richard L.; Ross, Robert J. H.; Hainey, Kirsten J. et al.
In: Nature Communications, Vol. 7, 10288, 06.01.2016.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Mort, RL, Ross, RJH, Hainey, KJ, Harrison, OJ, Keighren, MA, Landini, G, Baker, RE, Painter, KJ, Jackson, IJ & Yates, CA 2016, 'Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model', Nature Communications, vol. 7, 10288. https://doi.org/10.1038/ncomms10288

APA

Mort, R. L., Ross, R. J. H., Hainey, K. J., Harrison, O. J., Keighren, M. A., Landini, G., Baker, R. E., Painter, K. J., Jackson, I. J., & Yates, C. A. (2016). Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nature Communications, 7, Article 10288. https://doi.org/10.1038/ncomms10288

Vancouver

Mort RL, Ross RJH, Hainey KJ, Harrison OJ, Keighren MA, Landini G et al. Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nature Communications. 2016 Jan 6;7:10288. doi: 10.1038/ncomms10288

Author

Mort, Richard L. ; Ross, Robert J. H. ; Hainey, Kirsten J. et al. / Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. In: Nature Communications. 2016 ; Vol. 7.

Bibtex

@article{72f88f6c924244948b122795ac300e5c,
title = "Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model",
abstract = "Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented 'belly spots' in mice with mutations in the receptor tyrosine kinase Kit are thought to represent a failure of this colonization, either due to impaired migration or proliferation. Tracing of single melanoblast clones, however, has revealed a diffuse distribution with high levels of axial mixing--hard to reconcile with directed migration. Here we construct an agent-based stochastic model calibrated by experimental measurements to investigate the formation of diffuse clones, chimeric stripes and belly spots. Our observations indicate that melanoblast colonization likely proceeds through a process of undirected migration, proliferation and tissue expansion, and that reduced proliferation is the cause of the belly spots in Kit mutants.",
keywords = "Animals, Embryo, Mammalian, Mice, Models, Biological, Pigments, Biological, Skin, Tissue Culture Techniques, Journal Article, Research Support, Non-U.S. Gov't",
author = "Mort, {Richard L.} and Ross, {Robert J. H.} and Hainey, {Kirsten J.} and Harrison, {Olivia J.} and Keighren, {Margaret A.} and Gabriel Landini and Baker, {Ruth E.} and Painter, {Kevin J.} and Jackson, {Ian J.} and Yates, {Christian A.}",
year = "2016",
month = jan,
day = "6",
doi = "10.1038/ncomms10288",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model

AU - Mort, Richard L.

AU - Ross, Robert J. H.

AU - Hainey, Kirsten J.

AU - Harrison, Olivia J.

AU - Keighren, Margaret A.

AU - Landini, Gabriel

AU - Baker, Ruth E.

AU - Painter, Kevin J.

AU - Jackson, Ian J.

AU - Yates, Christian A.

PY - 2016/1/6

Y1 - 2016/1/6

N2 - Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented 'belly spots' in mice with mutations in the receptor tyrosine kinase Kit are thought to represent a failure of this colonization, either due to impaired migration or proliferation. Tracing of single melanoblast clones, however, has revealed a diffuse distribution with high levels of axial mixing--hard to reconcile with directed migration. Here we construct an agent-based stochastic model calibrated by experimental measurements to investigate the formation of diffuse clones, chimeric stripes and belly spots. Our observations indicate that melanoblast colonization likely proceeds through a process of undirected migration, proliferation and tissue expansion, and that reduced proliferation is the cause of the belly spots in Kit mutants.

AB - Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented 'belly spots' in mice with mutations in the receptor tyrosine kinase Kit are thought to represent a failure of this colonization, either due to impaired migration or proliferation. Tracing of single melanoblast clones, however, has revealed a diffuse distribution with high levels of axial mixing--hard to reconcile with directed migration. Here we construct an agent-based stochastic model calibrated by experimental measurements to investigate the formation of diffuse clones, chimeric stripes and belly spots. Our observations indicate that melanoblast colonization likely proceeds through a process of undirected migration, proliferation and tissue expansion, and that reduced proliferation is the cause of the belly spots in Kit mutants.

KW - Animals

KW - Embryo, Mammalian

KW - Mice

KW - Models, Biological

KW - Pigments, Biological

KW - Skin

KW - Tissue Culture Techniques

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ncomms10288

DO - 10.1038/ncomms10288

M3 - Journal article

C2 - 26732977

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 10288

ER -