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Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds

Research output: Contribution to journalJournal articlepeer-review

Published
<mark>Journal publication date</mark>4/06/2021
<mark>Journal</mark>Organic Letters
Issue number11
Volume23
Number of pages5
Pages (from-to)4463-4467
Publication StatusPublished
Early online date21/05/21
<mark>Original language</mark>English

Abstract

We describe, for the first time, a highly regioselective hydrosilylation of propargylic amines. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.