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Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. / Nunez, M. I.; McMillan, T. J.; Valenzuela, M. T.; Ruiz de Almodovar, J. M.; Pedraza, V.

In: Radiotherapy and Oncology, Vol. 39, No. 2, 05.1996, p. 155-165.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Nunez, MI, McMillan, TJ, Valenzuela, MT, Ruiz de Almodovar, JM & Pedraza, V 1996, 'Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells.', Radiotherapy and Oncology, vol. 39, no. 2, pp. 155-165. https://doi.org/10.1016/0167-8140(96)01732-X

APA

Nunez, M. I., McMillan, T. J., Valenzuela, M. T., Ruiz de Almodovar, J. M., & Pedraza, V. (1996). Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology, 39(2), 155-165. https://doi.org/10.1016/0167-8140(96)01732-X

Vancouver

Nunez MI, McMillan TJ, Valenzuela MT, Ruiz de Almodovar JM, Pedraza V. Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology. 1996 May;39(2):155-165. https://doi.org/10.1016/0167-8140(96)01732-X

Author

Nunez, M. I. ; McMillan, T. J. ; Valenzuela, M. T. ; Ruiz de Almodovar, J. M. ; Pedraza, V. / Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. In: Radiotherapy and Oncology. 1996 ; Vol. 39, No. 2. pp. 155-165.

Bibtex

@article{886b290944d64501a285288128ceb3a3,
title = "Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells.",
abstract = "The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at biologically relevant doses. In this review we present new data and summarize the role of the DNA double-strand breaks (dsb) induced by ionizing radiation and DNA dsb rejoining as determinants of cellular radiosensitivity. When cells were irradiated at high dose-rate, two molecular end-points were identified which often correlated with radiosensitivity: (1) the apparent number of DNA dsb induced per Gy per DNA unit and (2) the half-time of the fast component of the DNA dsb rejoining kinetics. These two molecular determinants, not mutually exclusive, may be linked through a common factor such as the conformation of DNA.",
keywords = "Author Keywords, Radiosensitivity, DNA double-strand breaks, Initial damage, Rejoining",
author = "Nunez, {M. I.} and McMillan, {T. J.} and Valenzuela, {M. T.} and {Ruiz de Almodovar}, {J. M.} and V. Pedraza",
year = "1996",
month = may,
doi = "10.1016/0167-8140(96)01732-X",
language = "English",
volume = "39",
pages = "155--165",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells.

AU - Nunez, M. I.

AU - McMillan, T. J.

AU - Valenzuela, M. T.

AU - Ruiz de Almodovar, J. M.

AU - Pedraza, V.

PY - 1996/5

Y1 - 1996/5

N2 - The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at biologically relevant doses. In this review we present new data and summarize the role of the DNA double-strand breaks (dsb) induced by ionizing radiation and DNA dsb rejoining as determinants of cellular radiosensitivity. When cells were irradiated at high dose-rate, two molecular end-points were identified which often correlated with radiosensitivity: (1) the apparent number of DNA dsb induced per Gy per DNA unit and (2) the half-time of the fast component of the DNA dsb rejoining kinetics. These two molecular determinants, not mutually exclusive, may be linked through a common factor such as the conformation of DNA.

AB - The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at biologically relevant doses. In this review we present new data and summarize the role of the DNA double-strand breaks (dsb) induced by ionizing radiation and DNA dsb rejoining as determinants of cellular radiosensitivity. When cells were irradiated at high dose-rate, two molecular end-points were identified which often correlated with radiosensitivity: (1) the apparent number of DNA dsb induced per Gy per DNA unit and (2) the half-time of the fast component of the DNA dsb rejoining kinetics. These two molecular determinants, not mutually exclusive, may be linked through a common factor such as the conformation of DNA.

KW - Author Keywords

KW - Radiosensitivity

KW - DNA double-strand breaks

KW - Initial damage

KW - Rejoining

U2 - 10.1016/0167-8140(96)01732-X

DO - 10.1016/0167-8140(96)01732-X

M3 - Journal article

VL - 39

SP - 155

EP - 165

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 2

ER -