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Remembered saccades with variable delay in Parkinson's disease

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Remembered saccades with variable delay in Parkinson's disease. / Shaunak, Sandip; O’Sullivan, Erin; Blunt, Staira et al.
In: Movement Disorders, Vol. 14, No. 1, 01.1999, p. 80-86.

Research output: Contribution to Journal/Magazine › Journal article

Harvard

Shaunak, S, O’Sullivan, E, Blunt, S, Lawden, M, Crawford, TJ, Henderson, L & Kennard, C 1999, 'Remembered saccades with variable delay in Parkinson's disease', Movement Disorders, vol. 14, no. 1, pp. 80-86. https://doi.org/10.1002/1531-8257(199901)14:1<80::AID-MDS1014>3.0.CO;2-M, https://doi.org/10.1002/1531-8257(199901)14:1<80::Aid-Mds1014>3.0.Co;2-M

APA

Shaunak, S., O’Sullivan, E., Blunt, S., Lawden, M., Crawford, T. J., Henderson, L., & Kennard, C. (1999). Remembered saccades with variable delay in Parkinson's disease. Movement Disorders, 14(1), 80-86. https://doi.org/10.1002/1531-8257(199901)14:1<80::AID-MDS1014>3.0.CO;2-M, https://doi.org/10.1002/1531-8257(199901)14:1<80::Aid-Mds1014>3.0.Co;2-M

Vancouver

Shaunak S, O’Sullivan E, Blunt S, Lawden M, Crawford TJ, Henderson L et al. Remembered saccades with variable delay in Parkinson's disease. Movement Disorders. 1999 Jan;14(1):80-86. doi: 10.1002/1531-8257(199901)14:1<80::AID-MDS1014>3.0.CO;2-M, 10.1002/1531-8257(199901)14:1<80::Aid-Mds1014>3.0.Co;2-M

Author

Shaunak, Sandip ; O’Sullivan, Erin ; Blunt, Staira et al. / Remembered saccades with variable delay in Parkinson's disease. In: Movement Disorders. 1999 ; Vol. 14, No. 1. pp. 80-86.

Bibtex

@article{118f4e36949d4dec91f2f4dba1b6e26b,
title = "Remembered saccades with variable delay in Parkinson's disease",
abstract = "The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L‐dopa, and nine age‐matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato‐collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.",
keywords = "Parkinson's disease, Remembered saccades, Basal ganglia, Dorsolateral prefrontal cortex, Spatial working memory",
author = "Sandip Shaunak and Erin O{\textquoteright}Sullivan and Staira Blunt and Mark Lawden and Crawford, {Trevor J.} and Leslie Henderson and Christopher Kennard",
year = "1999",
month = jan,
doi = "10.1002/1531-8257(199901)14:1<80::AID-MDS1014>3.0.CO;2-M",
language = "English",
volume = "14",
pages = "80--86",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Remembered saccades with variable delay in Parkinson's disease

AU - Shaunak, Sandip

AU - O’Sullivan, Erin

AU - Blunt, Staira

AU - Lawden, Mark

AU - Crawford, Trevor J.

AU - Henderson, Leslie

AU - Kennard, Christopher

PY - 1999/1

Y1 - 1999/1

N2 - The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L‐dopa, and nine age‐matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato‐collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.

AB - The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L‐dopa, and nine age‐matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato‐collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec.

KW - Parkinson's disease

KW - Remembered saccades

KW - Basal ganglia

KW - Dorsolateral prefrontal cortex

KW - Spatial working memory

U2 - 10.1002/1531-8257(199901)14:1<80::AID-MDS1014>3.0.CO;2-M

DO - 10.1002/1531-8257(199901)14:1<80::AID-MDS1014>3.0.CO;2-M

M3 - Journal article

VL - 14

SP - 80

EP - 86

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 1

ER -