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Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model

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Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model. / Deckmann, Iohanna; Santos-Terra, Júlio; Fontes-Dutra, Mellanie; Körbes-Rockenbach, Marília; Bauer-Negrini, Guilherme; Schwingel, Gustavo Brum; Riesgo, Rudimar; Bambini-Junior, Victorio; Gottfried, Carmem.

In: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, Vol. 81, No. 7, 30.11.2021, p. 579-604.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Deckmann, I, Santos-Terra, J, Fontes-Dutra, M, Körbes-Rockenbach, M, Bauer-Negrini, G, Schwingel, GB, Riesgo, R, Bambini-Junior, V & Gottfried, C 2021, 'Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model', International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, vol. 81, no. 7, pp. 579-604. https://doi.org/10.1002/jdn.10137

APA

Deckmann, I., Santos-Terra, J., Fontes-Dutra, M., Körbes-Rockenbach, M., Bauer-Negrini, G., Schwingel, G. B., Riesgo, R., Bambini-Junior, V., & Gottfried, C. (2021). Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 81(7), 579-604. https://doi.org/10.1002/jdn.10137

Vancouver

Deckmann I, Santos-Terra J, Fontes-Dutra M, Körbes-Rockenbach M, Bauer-Negrini G, Schwingel GB et al. Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2021 Nov 30;81(7):579-604. https://doi.org/10.1002/jdn.10137

Author

Deckmann, Iohanna ; Santos-Terra, Júlio ; Fontes-Dutra, Mellanie ; Körbes-Rockenbach, Marília ; Bauer-Negrini, Guilherme ; Schwingel, Gustavo Brum ; Riesgo, Rudimar ; Bambini-Junior, Victorio ; Gottfried, Carmem. / Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model. In: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2021 ; Vol. 81, No. 7. pp. 579-604.

Bibtex

@article{468f7c0cae4a4205bbc2ba882d41c6e9,
title = "Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model",
abstract = "Autism spectrum disorder can present a plethora of clinical conditions associated with the disorder, such as greater brain volume in the first years of life in a significant percentage of patients. We aimed to evaluate the brain water content, the blood-brain barrier permeability, and the expression of aquaporin 1 and 4, and GFAP in a valproic acid-animal model, assessing the effect of resveratrol. On postnatal day 30, Wistar rats of the valproic acid group showed greater permeability of the blood-brain barrier to the Evans blue dye and a higher proportion of brain water volume, prevented both by resveratrol. Prenatal exposition to valproic acid diminished aquaporin 1 in the choroid plexus, in the primary somatosensory area, in the amygdala region, and in the medial prefrontal cortex, reduced aquaporin 4 in medial prefrontal cortex and increased aquaporin 4 levels in primary somatosensory area (with resveratrol prevention). Valproic acid exposition also increased the number of astrocytes and GFAP fluorescence in both primary somatosensory area and medial prefrontal cortex. In medial prefrontal cortex, resveratrol prevented the increased fluorescence. Finally, there was an effect of resveratrol per se on the number of astrocytes and GFAP fluorescence in the amygdala region and in the hippocampus. Thus, this work demonstrates significant changes in blood-brain barrier permeability, edema formation, distribution of aquaporin 1 and 4, in addition to astrocytes profile in the animal model of autism, as well as the use of resveratrol as a tool to investigate the mechanisms involved in the pathophysiology of autism spectrum disorder.",
keywords = "Animals, Antioxidants/pharmacology, Aquaporin 4/metabolism, Astrocytes/metabolism, Autistic Disorder/metabolism, Blood-Brain Barrier/drug effects, Brain/drug effects, Brain Edema/prevention & control, Disease Models, Animal, Female, Male, Permeability/drug effects, Rats, Rats, Wistar, Resveratrol/pharmacology",
author = "Iohanna Deckmann and J{\'u}lio Santos-Terra and Mellanie Fontes-Dutra and Mar{\'i}lia K{\"o}rbes-Rockenbach and Guilherme Bauer-Negrini and Schwingel, {Gustavo Brum} and Rudimar Riesgo and Victorio Bambini-Junior and Carmem Gottfried",
note = "{\textcopyright} 2021 International Society for Developmental Neuroscience.",
year = "2021",
month = nov,
day = "30",
doi = "10.1002/jdn.10137",
language = "English",
volume = "81",
pages = "579--604",
journal = "International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience",
issn = "0736-5748",
publisher = "John Wiley & Sons Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Resveratrol prevents brain edema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model

AU - Deckmann, Iohanna

AU - Santos-Terra, Júlio

AU - Fontes-Dutra, Mellanie

AU - Körbes-Rockenbach, Marília

AU - Bauer-Negrini, Guilherme

AU - Schwingel, Gustavo Brum

AU - Riesgo, Rudimar

AU - Bambini-Junior, Victorio

AU - Gottfried, Carmem

N1 - © 2021 International Society for Developmental Neuroscience.

PY - 2021/11/30

Y1 - 2021/11/30

N2 - Autism spectrum disorder can present a plethora of clinical conditions associated with the disorder, such as greater brain volume in the first years of life in a significant percentage of patients. We aimed to evaluate the brain water content, the blood-brain barrier permeability, and the expression of aquaporin 1 and 4, and GFAP in a valproic acid-animal model, assessing the effect of resveratrol. On postnatal day 30, Wistar rats of the valproic acid group showed greater permeability of the blood-brain barrier to the Evans blue dye and a higher proportion of brain water volume, prevented both by resveratrol. Prenatal exposition to valproic acid diminished aquaporin 1 in the choroid plexus, in the primary somatosensory area, in the amygdala region, and in the medial prefrontal cortex, reduced aquaporin 4 in medial prefrontal cortex and increased aquaporin 4 levels in primary somatosensory area (with resveratrol prevention). Valproic acid exposition also increased the number of astrocytes and GFAP fluorescence in both primary somatosensory area and medial prefrontal cortex. In medial prefrontal cortex, resveratrol prevented the increased fluorescence. Finally, there was an effect of resveratrol per se on the number of astrocytes and GFAP fluorescence in the amygdala region and in the hippocampus. Thus, this work demonstrates significant changes in blood-brain barrier permeability, edema formation, distribution of aquaporin 1 and 4, in addition to astrocytes profile in the animal model of autism, as well as the use of resveratrol as a tool to investigate the mechanisms involved in the pathophysiology of autism spectrum disorder.

AB - Autism spectrum disorder can present a plethora of clinical conditions associated with the disorder, such as greater brain volume in the first years of life in a significant percentage of patients. We aimed to evaluate the brain water content, the blood-brain barrier permeability, and the expression of aquaporin 1 and 4, and GFAP in a valproic acid-animal model, assessing the effect of resveratrol. On postnatal day 30, Wistar rats of the valproic acid group showed greater permeability of the blood-brain barrier to the Evans blue dye and a higher proportion of brain water volume, prevented both by resveratrol. Prenatal exposition to valproic acid diminished aquaporin 1 in the choroid plexus, in the primary somatosensory area, in the amygdala region, and in the medial prefrontal cortex, reduced aquaporin 4 in medial prefrontal cortex and increased aquaporin 4 levels in primary somatosensory area (with resveratrol prevention). Valproic acid exposition also increased the number of astrocytes and GFAP fluorescence in both primary somatosensory area and medial prefrontal cortex. In medial prefrontal cortex, resveratrol prevented the increased fluorescence. Finally, there was an effect of resveratrol per se on the number of astrocytes and GFAP fluorescence in the amygdala region and in the hippocampus. Thus, this work demonstrates significant changes in blood-brain barrier permeability, edema formation, distribution of aquaporin 1 and 4, in addition to astrocytes profile in the animal model of autism, as well as the use of resveratrol as a tool to investigate the mechanisms involved in the pathophysiology of autism spectrum disorder.

KW - Animals

KW - Antioxidants/pharmacology

KW - Aquaporin 4/metabolism

KW - Astrocytes/metabolism

KW - Autistic Disorder/metabolism

KW - Blood-Brain Barrier/drug effects

KW - Brain/drug effects

KW - Brain Edema/prevention & control

KW - Disease Models, Animal

KW - Female

KW - Male

KW - Permeability/drug effects

KW - Rats

KW - Rats, Wistar

KW - Resveratrol/pharmacology

U2 - 10.1002/jdn.10137

DO - 10.1002/jdn.10137

M3 - Journal article

C2 - 34196408

VL - 81

SP - 579

EP - 604

JO - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

JF - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

SN - 0736-5748

IS - 7

ER -