Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Resveratrol prevents social deficits in animal model of autism induced by valproic acid
AU - Bambini-Junior, Victorio
AU - Zanatta, Geancarlo
AU - Della Flora Nunes, Gustavo
AU - Mueller de Melo, Gabriela
AU - Michels, Marcus
AU - Fontes-Dutra, Mellanie
AU - Nogueira Freire, Valder
AU - Riesgo, Rudimar
AU - Gottfried, Carmem
N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2014/11/7
Y1 - 2014/11/7
N2 - Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). Considering the neuroprotective, antioxidant and anti-inflammatory effects of resveratrol (RSV), we investigated the influence of prenatal RSV treatment on social behaviors of a rodent model of autism induced by prenatal exposure to VPA. In the three-chambered apparatus test, the VPA group showed a reduced place preference conditioned by conspecific and no preference between exploring a wire-cage or a rat enclosed inside a wire cage, revealing sociability impairments. Prenatal administration of RSV prevented the VPA-induced social impairments evaluated in this study. A bioinformatics analysis was used to discard possible molecular interactions between VPA and RSV during administration. The interaction energy between RSV and VPA is weak and highly unstable, suggesting cellular effects instead of a single chemical process. In summary, the present study highlights a promising experimental strategy to evaluate new molecular targets possibly involved in the etiology of autism and developmental alterations implicated in neural and behavioral impairments in ASD.
AB - Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). Considering the neuroprotective, antioxidant and anti-inflammatory effects of resveratrol (RSV), we investigated the influence of prenatal RSV treatment on social behaviors of a rodent model of autism induced by prenatal exposure to VPA. In the three-chambered apparatus test, the VPA group showed a reduced place preference conditioned by conspecific and no preference between exploring a wire-cage or a rat enclosed inside a wire cage, revealing sociability impairments. Prenatal administration of RSV prevented the VPA-induced social impairments evaluated in this study. A bioinformatics analysis was used to discard possible molecular interactions between VPA and RSV during administration. The interaction energy between RSV and VPA is weak and highly unstable, suggesting cellular effects instead of a single chemical process. In summary, the present study highlights a promising experimental strategy to evaluate new molecular targets possibly involved in the etiology of autism and developmental alterations implicated in neural and behavioral impairments in ASD.
KW - Animals
KW - Anti-Inflammatory Agents/therapeutic use
KW - Autistic Disorder/drug therapy
KW - Female
KW - Male
KW - Maternal Exposure
KW - Molecular Dynamics Simulation
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects/drug therapy
KW - Rats, Wistar
KW - Resveratrol
KW - Social Skills
KW - Stilbenes/therapeutic use
KW - Valproic Acid/adverse effects
U2 - 10.1016/j.neulet.2014.09.039
DO - 10.1016/j.neulet.2014.09.039
M3 - Journal article
C2 - 25263788
VL - 583
SP - 176
EP - 181
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -