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Resveratrol prevents social deficits in animal model of autism induced by valproic acid

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Resveratrol prevents social deficits in animal model of autism induced by valproic acid. / Bambini-Junior, Victorio; Zanatta, Geancarlo; Della Flora Nunes, Gustavo et al.

In: Neuroscience Letters, Vol. 583, 07.11.2014, p. 176-181.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Bambini-Junior, V, Zanatta, G, Della Flora Nunes, G, Mueller de Melo, G, Michels, M, Fontes-Dutra, M, Nogueira Freire, V, Riesgo, R & Gottfried, C 2014, 'Resveratrol prevents social deficits in animal model of autism induced by valproic acid', Neuroscience Letters, vol. 583, pp. 176-181. https://doi.org/10.1016/j.neulet.2014.09.039

APA

Bambini-Junior, V., Zanatta, G., Della Flora Nunes, G., Mueller de Melo, G., Michels, M., Fontes-Dutra, M., Nogueira Freire, V., Riesgo, R., & Gottfried, C. (2014). Resveratrol prevents social deficits in animal model of autism induced by valproic acid. Neuroscience Letters, 583, 176-181. https://doi.org/10.1016/j.neulet.2014.09.039

Vancouver

Bambini-Junior V, Zanatta G, Della Flora Nunes G, Mueller de Melo G, Michels M, Fontes-Dutra M et al. Resveratrol prevents social deficits in animal model of autism induced by valproic acid. Neuroscience Letters. 2014 Nov 7;583:176-181. Epub 2014 Sep 28. doi: 10.1016/j.neulet.2014.09.039

Author

Bambini-Junior, Victorio ; Zanatta, Geancarlo ; Della Flora Nunes, Gustavo et al. / Resveratrol prevents social deficits in animal model of autism induced by valproic acid. In: Neuroscience Letters. 2014 ; Vol. 583. pp. 176-181.

Bibtex

@article{07f6ebeaba0e4280aa69d243007493d9,
title = "Resveratrol prevents social deficits in animal model of autism induced by valproic acid",
abstract = "Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). Considering the neuroprotective, antioxidant and anti-inflammatory effects of resveratrol (RSV), we investigated the influence of prenatal RSV treatment on social behaviors of a rodent model of autism induced by prenatal exposure to VPA. In the three-chambered apparatus test, the VPA group showed a reduced place preference conditioned by conspecific and no preference between exploring a wire-cage or a rat enclosed inside a wire cage, revealing sociability impairments. Prenatal administration of RSV prevented the VPA-induced social impairments evaluated in this study. A bioinformatics analysis was used to discard possible molecular interactions between VPA and RSV during administration. The interaction energy between RSV and VPA is weak and highly unstable, suggesting cellular effects instead of a single chemical process. In summary, the present study highlights a promising experimental strategy to evaluate new molecular targets possibly involved in the etiology of autism and developmental alterations implicated in neural and behavioral impairments in ASD. ",
keywords = "Animals, Anti-Inflammatory Agents/therapeutic use, Autistic Disorder/drug therapy, Female, Male, Maternal Exposure, Molecular Dynamics Simulation, Pregnancy, Prenatal Exposure Delayed Effects/drug therapy, Rats, Wistar, Resveratrol, Social Skills, Stilbenes/therapeutic use, Valproic Acid/adverse effects",
author = "Victorio Bambini-Junior and Geancarlo Zanatta and {Della Flora Nunes}, Gustavo and {Mueller de Melo}, Gabriela and Marcus Michels and Mellanie Fontes-Dutra and {Nogueira Freire}, Valder and Rudimar Riesgo and Carmem Gottfried",
note = "Copyright {\textcopyright} 2014 Elsevier Ireland Ltd. All rights reserved.",
year = "2014",
month = nov,
day = "7",
doi = "10.1016/j.neulet.2014.09.039",
language = "English",
volume = "583",
pages = "176--181",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "ELSEVIER IRELAND LTD",

}

RIS

TY - JOUR

T1 - Resveratrol prevents social deficits in animal model of autism induced by valproic acid

AU - Bambini-Junior, Victorio

AU - Zanatta, Geancarlo

AU - Della Flora Nunes, Gustavo

AU - Mueller de Melo, Gabriela

AU - Michels, Marcus

AU - Fontes-Dutra, Mellanie

AU - Nogueira Freire, Valder

AU - Riesgo, Rudimar

AU - Gottfried, Carmem

N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

PY - 2014/11/7

Y1 - 2014/11/7

N2 - Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). Considering the neuroprotective, antioxidant and anti-inflammatory effects of resveratrol (RSV), we investigated the influence of prenatal RSV treatment on social behaviors of a rodent model of autism induced by prenatal exposure to VPA. In the three-chambered apparatus test, the VPA group showed a reduced place preference conditioned by conspecific and no preference between exploring a wire-cage or a rat enclosed inside a wire cage, revealing sociability impairments. Prenatal administration of RSV prevented the VPA-induced social impairments evaluated in this study. A bioinformatics analysis was used to discard possible molecular interactions between VPA and RSV during administration. The interaction energy between RSV and VPA is weak and highly unstable, suggesting cellular effects instead of a single chemical process. In summary, the present study highlights a promising experimental strategy to evaluate new molecular targets possibly involved in the etiology of autism and developmental alterations implicated in neural and behavioral impairments in ASD.

AB - Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). Considering the neuroprotective, antioxidant and anti-inflammatory effects of resveratrol (RSV), we investigated the influence of prenatal RSV treatment on social behaviors of a rodent model of autism induced by prenatal exposure to VPA. In the three-chambered apparatus test, the VPA group showed a reduced place preference conditioned by conspecific and no preference between exploring a wire-cage or a rat enclosed inside a wire cage, revealing sociability impairments. Prenatal administration of RSV prevented the VPA-induced social impairments evaluated in this study. A bioinformatics analysis was used to discard possible molecular interactions between VPA and RSV during administration. The interaction energy between RSV and VPA is weak and highly unstable, suggesting cellular effects instead of a single chemical process. In summary, the present study highlights a promising experimental strategy to evaluate new molecular targets possibly involved in the etiology of autism and developmental alterations implicated in neural and behavioral impairments in ASD.

KW - Animals

KW - Anti-Inflammatory Agents/therapeutic use

KW - Autistic Disorder/drug therapy

KW - Female

KW - Male

KW - Maternal Exposure

KW - Molecular Dynamics Simulation

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects/drug therapy

KW - Rats, Wistar

KW - Resveratrol

KW - Social Skills

KW - Stilbenes/therapeutic use

KW - Valproic Acid/adverse effects

U2 - 10.1016/j.neulet.2014.09.039

DO - 10.1016/j.neulet.2014.09.039

M3 - Journal article

C2 - 25263788

VL - 583

SP - 176

EP - 181

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -