Final published version
Research output: Book/Report/Proceedings › Commissioned report
Research output: Book/Report/Proceedings › Commissioned report
}
TY - BOOK
T1 - Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments
AU - NASEM
AU - Whaley, Paul
PY - 2021/11/30
Y1 - 2021/11/30
N2 - The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) program develops human health assessments that focus on hazard identification and dose-response analyses for chemicals in the environment. The ORD Staff Handbook for Developing IRIS Assessments (the handbook) provides guidance to scientists who perform the IRIS assessments in order to foster consistency in the assessments and enhance transparency about the IRIS assessment process. At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties.
AB - The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) program develops human health assessments that focus on hazard identification and dose-response analyses for chemicals in the environment. The ORD Staff Handbook for Developing IRIS Assessments (the handbook) provides guidance to scientists who perform the IRIS assessments in order to foster consistency in the assessments and enhance transparency about the IRIS assessment process. At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties.
KW - Systematic Review
KW - chemical risk assessment
U2 - 10.17226/26289
DO - 10.17226/26289
M3 - Commissioned report
BT - Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments
PB - National Academy of Sciences
ER -