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Rhenium and Iridium Complexes and their Interaction with DNA

Research output: Thesis › Master's Thesis

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Rhenium and Iridium Complexes and their Interaction with DNA. / Patel, Humaira.
Lancaster University, 2023. 68 p.

Research output: Thesis › Master's Thesis

Harvard

Patel, H 2023, 'Rhenium and Iridium Complexes and their Interaction with DNA', Masters by Research, Lancaster University. https://doi.org/10.17635/lancaster/thesis/1957

APA

Patel, H. (2023). Rhenium and Iridium Complexes and their Interaction with DNA. [Master's Thesis, Lancaster University]. Lancaster University. https://doi.org/10.17635/lancaster/thesis/1957

Vancouver

Patel H. Rhenium and Iridium Complexes and their Interaction with DNA. Lancaster University, 2023. 68 p. doi: 10.17635/lancaster/thesis/1957

Author

Patel, Humaira. / Rhenium and Iridium Complexes and their Interaction with DNA. Lancaster University, 2023. 68 p.

Bibtex

@mastersthesis{ed79de754a7041cfa6b29f3200afd3a2,
title = "Rhenium and Iridium Complexes and their Interaction with DNA",
abstract = "The Fletcher group has previously explored the ruthenium complexes of 4,4{\textquoteright}-bis(benzoxazole-2-yl)-2,2{\textquoteright}-bipyridine (BBOB), 4,4{\textquoteright}-bis(benzothiazole-2-yl)-2,2{\textquoteright}-bipyridine (BBTB), and 4,4{\textquoteright}-bis(benzimidazole-2-yl-2,2{\textquoteright}-bipyridine (BBIB) and shown that they typically bind in the minor groove of DNA, rather than intercalate, having a preference for defect sites such as bulges and hairpin loops. We report here the synthesis of a series of related ligands, and their complexation to both rhenium(I) and iridium(III), via reaction with Re(CO)5Br and {Ir(ppy)2(Cl)}2 respectively. These have been characterized through NMR, infrared and UV-Vis absorption and emission spectroscopy, illustrating the effect of conjugation of the extended heterocyclic structure. Despite solubility issues, we will discuss here the photophysical analysis, including circular dichroism (CD) spectroscopic studies, which show that these complexes interact with DNA and highlight a new potential DNA binding mode. ",
author = "Humaira Patel",
year = "2023",
month = mar,
day = "4",
doi = "10.17635/lancaster/thesis/1957",
language = "English",
publisher = "Lancaster University",
school = "Lancaster University",

}

RIS

TY - THES

T1 - Rhenium and Iridium Complexes and their Interaction with DNA

AU - Patel, Humaira

PY - 2023/3/4

Y1 - 2023/3/4

N2 - The Fletcher group has previously explored the ruthenium complexes of 4,4’-bis(benzoxazole-2-yl)-2,2’-bipyridine (BBOB), 4,4’-bis(benzothiazole-2-yl)-2,2’-bipyridine (BBTB), and 4,4’-bis(benzimidazole-2-yl-2,2’-bipyridine (BBIB) and shown that they typically bind in the minor groove of DNA, rather than intercalate, having a preference for defect sites such as bulges and hairpin loops. We report here the synthesis of a series of related ligands, and their complexation to both rhenium(I) and iridium(III), via reaction with Re(CO)5Br and {Ir(ppy)2(Cl)}2 respectively. These have been characterized through NMR, infrared and UV-Vis absorption and emission spectroscopy, illustrating the effect of conjugation of the extended heterocyclic structure. Despite solubility issues, we will discuss here the photophysical analysis, including circular dichroism (CD) spectroscopic studies, which show that these complexes interact with DNA and highlight a new potential DNA binding mode.

AB - The Fletcher group has previously explored the ruthenium complexes of 4,4’-bis(benzoxazole-2-yl)-2,2’-bipyridine (BBOB), 4,4’-bis(benzothiazole-2-yl)-2,2’-bipyridine (BBTB), and 4,4’-bis(benzimidazole-2-yl-2,2’-bipyridine (BBIB) and shown that they typically bind in the minor groove of DNA, rather than intercalate, having a preference for defect sites such as bulges and hairpin loops. We report here the synthesis of a series of related ligands, and their complexation to both rhenium(I) and iridium(III), via reaction with Re(CO)5Br and {Ir(ppy)2(Cl)}2 respectively. These have been characterized through NMR, infrared and UV-Vis absorption and emission spectroscopy, illustrating the effect of conjugation of the extended heterocyclic structure. Despite solubility issues, we will discuss here the photophysical analysis, including circular dichroism (CD) spectroscopic studies, which show that these complexes interact with DNA and highlight a new potential DNA binding mode.

U2 - 10.17635/lancaster/thesis/1957

DO - 10.17635/lancaster/thesis/1957

M3 - Master's Thesis

PB - Lancaster University

ER -