Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Risk-Based Colposcopy for Cervical Precancer Detection
T2 - A Cross-Sectional Multicenter Study in China
AU - Xue, Peng
AU - Seery, Samuel
AU - Li, Qing
AU - Jiang, Yu
AU - Qiao, Youlin
A2 - Knez, Jure
PY - 2022/10/25
Y1 - 2022/10/25
N2 - Recently published guidelines depend upon screening for cervical precancer risk stratification; however, colposcopy provides key information. There is no data from developing countries that could be used comparatively. Therefore, we assessed the potential benefits of intercalating colposcopic impressions with screening results to detect cervical precancers through a multicenter, cross-sectional study of a Chinese population. Anonymized data from 6012 women with cytologic assessment, human papillomavirus (HPV) testing, colposcopic impressions, and histological results were analyzed. Univariate and multivariate analysis showed that high-grade squamous intraepithelial lesion (HSIL) cytology, HPV16/18+, and/or high-grade colposcopic impressions markedly increased cervical precancer risk, while high-grade colposcopic impressions were associated with the highest risk. The risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) ranged from 0% for normal/benign colposcopic impressions, 19% increased risk of CIN3+, even in participants without HSIL+ cytology and/or HPV16/18+. Regardless of screening outcomes, normal/benign colposcopic impressions were associated with the lowest risk of CIN3+ (
AB - Recently published guidelines depend upon screening for cervical precancer risk stratification; however, colposcopy provides key information. There is no data from developing countries that could be used comparatively. Therefore, we assessed the potential benefits of intercalating colposcopic impressions with screening results to detect cervical precancers through a multicenter, cross-sectional study of a Chinese population. Anonymized data from 6012 women with cytologic assessment, human papillomavirus (HPV) testing, colposcopic impressions, and histological results were analyzed. Univariate and multivariate analysis showed that high-grade squamous intraepithelial lesion (HSIL) cytology, HPV16/18+, and/or high-grade colposcopic impressions markedly increased cervical precancer risk, while high-grade colposcopic impressions were associated with the highest risk. The risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) ranged from 0% for normal/benign colposcopic impressions, 19% increased risk of CIN3+, even in participants without HSIL+ cytology and/or HPV16/18+. Regardless of screening outcomes, normal/benign colposcopic impressions were associated with the lowest risk of CIN3+ (
KW - Article
KW - cervical cancer screening
KW - colposcopy
KW - precancer
KW - risk assessment
U2 - 10.3390/diagnostics12112585
DO - 10.3390/diagnostics12112585
M3 - Journal article
VL - 12
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 11
M1 - 2585
ER -