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RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection. / Griffiths, Samantha; Portman, Neil; Taylor, Philip R. et al.
In: Eukaryotic Cell, Vol. 6, No. 7, 07.2007, p. 1248-1250.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Griffiths, S, Portman, N, Taylor, PR, Gordon, S, Ginger, ML & Gull, K 2007, 'RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection.', Eukaryotic Cell, vol. 6, no. 7, pp. 1248-1250. https://doi.org/10.1128/EC.00110-07

APA

Griffiths, S., Portman, N., Taylor, P. R., Gordon, S., Ginger, M. L., & Gull, K. (2007). RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection. Eukaryotic Cell, 6(7), 1248-1250. https://doi.org/10.1128/EC.00110-07

Vancouver

Griffiths S, Portman N, Taylor PR, Gordon S, Ginger ML, Gull K. RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection. Eukaryotic Cell. 2007 Jul;6(7):1248-1250. doi: 10.1128/EC.00110-07

Author

Griffiths, Samantha ; Portman, Neil ; Taylor, Philip R. et al. / RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection. In: Eukaryotic Cell. 2007 ; Vol. 6, No. 7. pp. 1248-1250.

Bibtex

@article{6db7b00a4e7b4f24ae730d847a657200,
title = "RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection.",
abstract = "We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.",
author = "Samantha Griffiths and Neil Portman and Taylor, {Philip R.} and Siamon Gordon and Ginger, {Michael L.} and Keith Gull",
year = "2007",
month = jul,
doi = "10.1128/EC.00110-07",
language = "English",
volume = "6",
pages = "1248--1250",
journal = "Eukaryotic Cell",
issn = "1535-9778",
publisher = "American Society for Microbiology",
number = "7",

}

RIS

TY - JOUR

T1 - RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection.

AU - Griffiths, Samantha

AU - Portman, Neil

AU - Taylor, Philip R.

AU - Gordon, Siamon

AU - Ginger, Michael L.

AU - Gull, Keith

PY - 2007/7

Y1 - 2007/7

N2 - We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

AB - We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

U2 - 10.1128/EC.00110-07

DO - 10.1128/EC.00110-07

M3 - Journal article

VL - 6

SP - 1248

EP - 1250

JO - Eukaryotic Cell

JF - Eukaryotic Cell

SN - 1535-9778

IS - 7

ER -