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Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Klaus Winzer
  • Yao-hui Sun
  • Andrew Green
  • Marie Delory
  • David Blackley
  • Kim R. Hardie
  • Thomas J. Baldwin
  • Christoph M. Tang
<mark>Journal publication date</mark>04/2002
<mark>Journal</mark>Infection and Immunity
Issue number4
Number of pages4
Pages (from-to)2245-2248
Publication StatusPublished
<mark>Original language</mark>English


Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.