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Ruthenium-Catalyzed N-Alkylation of Amines and Sulfonamides Using Borrowing Hydrogen Methodology

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  • M. Haniti S. A. Hamid
  • C. Liana Allen
  • Gareth W. Lamb
  • Aoife C. Maxwell
  • Hannah Maytum
  • Andrew J. A. Watson
  • Jonathan M. J. Williams
<mark>Journal publication date</mark>11/02/2009
<mark>Journal</mark>Journal of the American Chemical Society
Issue number5
Number of pages9
Pages (from-to)1766-1774
Publication StatusPublished
Early online date21/01/09
<mark>Original language</mark>English


The alkylation of amines by alcohols has been achieved using 0.5 mol % [Ru(p-cymene)Cl(2)](2) with the bidentate phosphines dppf or DPEphos as the catalyst. Primary amines have been converted into secondary amines, and secondary amines into tertiary amines, including the syntheses of Piribedil, Tripelennamine, and Chlorpheniramine. N-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols require more forcing conditions than primary alcohols but are still effective alkylating agents in the presence of this catalyst.