Research output: Contribution to Journal/Magazine › Literature review › peer-review
Research output: Contribution to Journal/Magazine › Literature review › peer-review
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TY - JOUR
T1 - (S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis
AU - Longbottom, Deborah A.
AU - Franckevicius, Vilius
AU - Ley, Steven V.
PY - 2007
Y1 - 2007
N2 - This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-l H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of each reaction type for which they have proved to be efficient catalytic species. Where relevant, a comparison is made with other organocatalysts in similar asymmetric reaction processes.
AB - This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-l H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of each reaction type for which they have proved to be efficient catalytic species. Where relevant, a comparison is made with other organocatalysts in similar asymmetric reaction processes.
KW - ENANTIOSELECTIVE ALPHA-AMINOMETHYLATION
KW - AMINO-ACIDS
KW - 3-COMPONENT MANNICH REACTION
KW - CONJUGATE ADDITION
KW - organocatalysis
KW - tetrazole
KW - DIPOLAR APROTIC MEDIA
KW - proline
KW - EFFICIENT TOTAL-SYNTHESIS
KW - asymmetric
KW - INTERMOLECULAR ALDOL REACTIONS
KW - synthesis
KW - BETA-KETO-ESTERS
KW - ASYMMETRIC MICHAEL ADDITION
KW - DIELS-ALDER REACTIONS
U2 - 10.2533/chimia.2007.247
DO - 10.2533/chimia.2007.247
M3 - Literature review
VL - 61
SP - 247
EP - 256
JO - CHIMIA
JF - CHIMIA
SN - 0009-4293
IS - 5
ER -