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Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients

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Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients. / Crawford, T. J.; Haeger, B.; Kennard, C.; Reveley, M. A.; Henderson, L.

In: Psychological Medicine, Vol. 25, No. 3, 05.1995, p. 461-471.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Crawford, TJ, Haeger, B, Kennard, C, Reveley, MA & Henderson, L 1995, 'Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients', Psychological Medicine, vol. 25, no. 3, pp. 461-471. https://doi.org/10.1017/S0033291700033389

APA

Crawford, T. J., Haeger, B., Kennard, C., Reveley, M. A., & Henderson, L. (1995). Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients. Psychological Medicine, 25(3), 461-471. https://doi.org/10.1017/S0033291700033389

Vancouver

Crawford TJ, Haeger B, Kennard C, Reveley MA, Henderson L. Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients. Psychological Medicine. 1995 May;25(3):461-471. https://doi.org/10.1017/S0033291700033389

Author

Crawford, T. J. ; Haeger, B. ; Kennard, C. ; Reveley, M. A. ; Henderson, L. / Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients. In: Psychological Medicine. 1995 ; Vol. 25, No. 3. pp. 461-471.

Bibtex

@article{479241ad998c40609df86da16d57c654,
title = "Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients",
abstract = "Most of the previous research reporting abnormalities of rapid re-fixation eye movements (saccades) in patients with schizophrenia has used patients receiving neuroleptic medication. In this study non-neuroleptically medicated schizophrenics were compared with other psychiatric patients using a variety of saccadic paradigms to determine the specificity of saccadic dysfunction. The patient groups consisted of schizophrenics (N = 18), bipolar affectives (N = 18), anxiety neurotics (N = 10) and normal controls (N = 31), none of whom had received neuroleptic medication for the preceding 6 months. Four behavioural paradigms, reflexive, predictive, remembered and ANTI were used to elicit saccades. The primary abnormality in the schizophrenic group was a significantly increased rate of distractibility in the ANTI (saccades made towards the target rather than in an opposite direction) and REM (saccades made prior to the imperative cue) paradigms. The major neuropsychological variable predictive of these errors was Wisconsin card sort perseverative errors. These data, in conjunction with findings from previous neurological research, would seem to provide converging evidence towards dysfunction of prefrontal cortex in schizophrenia.",
author = "Crawford, {T. J.} and B. Haeger and C. Kennard and Reveley, {M. A.} and L. Henderson",
year = "1995",
month = may,
doi = "10.1017/S0033291700033389",
language = "English",
volume = "25",
pages = "461--471",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Saccadic Abnormalities in Psychotic-Patients .1. Neuroleptic-Free Psychotic-Patients

AU - Crawford, T. J.

AU - Haeger, B.

AU - Kennard, C.

AU - Reveley, M. A.

AU - Henderson, L.

PY - 1995/5

Y1 - 1995/5

N2 - Most of the previous research reporting abnormalities of rapid re-fixation eye movements (saccades) in patients with schizophrenia has used patients receiving neuroleptic medication. In this study non-neuroleptically medicated schizophrenics were compared with other psychiatric patients using a variety of saccadic paradigms to determine the specificity of saccadic dysfunction. The patient groups consisted of schizophrenics (N = 18), bipolar affectives (N = 18), anxiety neurotics (N = 10) and normal controls (N = 31), none of whom had received neuroleptic medication for the preceding 6 months. Four behavioural paradigms, reflexive, predictive, remembered and ANTI were used to elicit saccades. The primary abnormality in the schizophrenic group was a significantly increased rate of distractibility in the ANTI (saccades made towards the target rather than in an opposite direction) and REM (saccades made prior to the imperative cue) paradigms. The major neuropsychological variable predictive of these errors was Wisconsin card sort perseverative errors. These data, in conjunction with findings from previous neurological research, would seem to provide converging evidence towards dysfunction of prefrontal cortex in schizophrenia.

AB - Most of the previous research reporting abnormalities of rapid re-fixation eye movements (saccades) in patients with schizophrenia has used patients receiving neuroleptic medication. In this study non-neuroleptically medicated schizophrenics were compared with other psychiatric patients using a variety of saccadic paradigms to determine the specificity of saccadic dysfunction. The patient groups consisted of schizophrenics (N = 18), bipolar affectives (N = 18), anxiety neurotics (N = 10) and normal controls (N = 31), none of whom had received neuroleptic medication for the preceding 6 months. Four behavioural paradigms, reflexive, predictive, remembered and ANTI were used to elicit saccades. The primary abnormality in the schizophrenic group was a significantly increased rate of distractibility in the ANTI (saccades made towards the target rather than in an opposite direction) and REM (saccades made prior to the imperative cue) paradigms. The major neuropsychological variable predictive of these errors was Wisconsin card sort perseverative errors. These data, in conjunction with findings from previous neurological research, would seem to provide converging evidence towards dysfunction of prefrontal cortex in schizophrenia.

U2 - 10.1017/S0033291700033389

DO - 10.1017/S0033291700033389

M3 - Journal article

VL - 25

SP - 461

EP - 471

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 3

ER -