TY - JOUR

T1 - Saccadic Eye Movements in Parkinson's Disease: I. Delayed Saccades

AU - Lueck, C. J.

AU - Tanyeri, S.

AU - Kennard, C.

AU - Crawford, Trevor

AU - Henderson, L.

PY - 1992

Y1 - 1992

N2 - The saccadic eye movements of nine patients with Parkinson’s disease werecompared to those of nine age-matched controls in two paradigms generatingvolitional saccades. In both paradigms. subjects had to make delayedsaccades to peripheral LED targets: a peripheral target appeared 700 msecbefore a buzzer sounded, the buzzer being the signal to make a saccade tothe target. In the first paradigm (“centre-off“), the fixation target wasextinguished simultaneously with buzzer onset. In the second (“centreremain”)it was not extinguished until 1000 msec later. The results showedthat for outward saccades in both paradigms, there was no difference betweenParkinsonian patients and controls, but saccadic latencies were significantlyshorter in the “centre-remain” paradigm. The initial outward saccades wereindistinguishable from the normal, reflex saccades of the same subjects.However, saccades returning to the centre (a type of remembered targetsaccade) were hypometric and showed multistepping. Both effects were morepronounced in patients with Parkinson’s disease. The significance of thesefindings in terms of current hypotheses about the nature of the Parkinsoniansaccadic deficit is discussed.

AB - The saccadic eye movements of nine patients with Parkinson’s disease werecompared to those of nine age-matched controls in two paradigms generatingvolitional saccades. In both paradigms. subjects had to make delayedsaccades to peripheral LED targets: a peripheral target appeared 700 msecbefore a buzzer sounded, the buzzer being the signal to make a saccade tothe target. In the first paradigm (“centre-off“), the fixation target wasextinguished simultaneously with buzzer onset. In the second (“centreremain”)it was not extinguished until 1000 msec later. The results showedthat for outward saccades in both paradigms, there was no difference betweenParkinsonian patients and controls, but saccadic latencies were significantlyshorter in the “centre-remain” paradigm. The initial outward saccades wereindistinguishable from the normal, reflex saccades of the same subjects.However, saccades returning to the centre (a type of remembered targetsaccade) were hypometric and showed multistepping. Both effects were morepronounced in patients with Parkinson’s disease. The significance of thesefindings in terms of current hypotheses about the nature of the Parkinsoniansaccadic deficit is discussed.

KW - Saccade

KW - Parkinson's disease

U2 - 10.1080/14640749208401324

DO - 10.1080/14640749208401324

M3 - Journal article

VL - 45

SP - 193

EP - 210

JO - Quarterly Journal of Experimental Psychology Series a Human Experimental Psychology

JF - Quarterly Journal of Experimental Psychology Series a Human Experimental Psychology

SN - 0272-4987

IS - 2

ER -