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Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: A working memory deficit?

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: A working memory deficit? / Hutton, S. B.; Cuthbert, I.; Crawford, T. J. et al.
In: Psychophysiology, Vol. 38, No. 1, 01.2001, p. 125-132.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hutton, SB, Cuthbert, I, Crawford, TJ, Kennard, C, Barnes, TRE & Joyce, EM 2001, 'Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: A working memory deficit?', Psychophysiology, vol. 38, no. 1, pp. 125-132. https://doi.org/10.1017/S0048577201992169

APA

Hutton, S. B., Cuthbert, I., Crawford, T. J., Kennard, C., Barnes, T. R. E., & Joyce, E. M. (2001). Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: A working memory deficit? Psychophysiology, 38(1), 125-132. https://doi.org/10.1017/S0048577201992169

Vancouver

Hutton SB, Cuthbert I, Crawford TJ, Kennard C, Barnes TRE, Joyce EM. Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: A working memory deficit? Psychophysiology. 2001 Jan;38(1):125-132. doi: 10.1017/S0048577201992169

Author

Hutton, S. B. ; Cuthbert, I. ; Crawford, T. J. et al. / Saccadic hypometria in drug-naive and drug-treated schizophrenic patients : A working memory deficit?. In: Psychophysiology. 2001 ; Vol. 38, No. 1. pp. 125-132.

Bibtex

@article{1c181f744460434e8bcdd15b9225423d,
title = "Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: A working memory deficit?",
abstract = "In certain conditions patients with schizophrenia make markedly smaller (hypometric) saccades than controls. This hypometria has been thought to reflect dopaminergic blockade as a result of antipsychotic medication. We tested this hypothesis by comparing the performance of an antipsychotic‐na{\"i}ve group and an antipsychotic‐treated group of first‐episode schizophrenic patients on a predictive saccade paradigm. We explored the possibility that hypometria reflects a spatial working memory deficit by correlating performance on neuropsychological tests of mnemonic function with saccadic accuracy. Both the drug‐na{\"i}ve and treated schizophrenic patients made hypometric saccades when compared with a group of matched controls. Primary saccade amplitude also correlated significantly with performance on some of the neuropsychological tests. These results are discussed in terms of the roles of cortical dopamine and working memory deficits in schizophrenic patients.",
keywords = "Predictive saccades, Schizophrenia, Working memory, Drug‐na{\"i}ve, Hypometria, First‐episode",
author = "Hutton, {S. B.} and I. Cuthbert and Crawford, {T. J.} and C. Kennard and Barnes, {T. R. E.} and Joyce, {E. M.}",
year = "2001",
month = jan,
doi = "10.1017/S0048577201992169",
language = "English",
volume = "38",
pages = "125--132",
journal = "Psychophysiology",
issn = "0048-5772",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "1",

}

RIS

TY - JOUR

T1 - Saccadic hypometria in drug-naive and drug-treated schizophrenic patients

T2 - A working memory deficit?

AU - Hutton, S. B.

AU - Cuthbert, I.

AU - Crawford, T. J.

AU - Kennard, C.

AU - Barnes, T. R. E.

AU - Joyce, E. M.

PY - 2001/1

Y1 - 2001/1

N2 - In certain conditions patients with schizophrenia make markedly smaller (hypometric) saccades than controls. This hypometria has been thought to reflect dopaminergic blockade as a result of antipsychotic medication. We tested this hypothesis by comparing the performance of an antipsychotic‐naïve group and an antipsychotic‐treated group of first‐episode schizophrenic patients on a predictive saccade paradigm. We explored the possibility that hypometria reflects a spatial working memory deficit by correlating performance on neuropsychological tests of mnemonic function with saccadic accuracy. Both the drug‐naïve and treated schizophrenic patients made hypometric saccades when compared with a group of matched controls. Primary saccade amplitude also correlated significantly with performance on some of the neuropsychological tests. These results are discussed in terms of the roles of cortical dopamine and working memory deficits in schizophrenic patients.

AB - In certain conditions patients with schizophrenia make markedly smaller (hypometric) saccades than controls. This hypometria has been thought to reflect dopaminergic blockade as a result of antipsychotic medication. We tested this hypothesis by comparing the performance of an antipsychotic‐naïve group and an antipsychotic‐treated group of first‐episode schizophrenic patients on a predictive saccade paradigm. We explored the possibility that hypometria reflects a spatial working memory deficit by correlating performance on neuropsychological tests of mnemonic function with saccadic accuracy. Both the drug‐naïve and treated schizophrenic patients made hypometric saccades when compared with a group of matched controls. Primary saccade amplitude also correlated significantly with performance on some of the neuropsychological tests. These results are discussed in terms of the roles of cortical dopamine and working memory deficits in schizophrenic patients.

KW - Predictive saccades

KW - Schizophrenia

KW - Working memory

KW - Drug‐naïve

KW - Hypometria

KW - First‐episode

U2 - 10.1017/S0048577201992169

DO - 10.1017/S0048577201992169

M3 - Journal article

VL - 38

SP - 125

EP - 132

JO - Psychophysiology

JF - Psychophysiology

SN - 0048-5772

IS - 1

ER -