Security, Trust and Reliability are crucial issues in mobile 5G networks from both hardware and software perspectives. These issues are of significant importance when considering implementations over distributed environments, i.e., corporate Cloud environment over massively virtualized infrastructures as envisioned in the 5G service provision paradigm. The SANCUS1 solution intends providing a modular framework integrating different engines in order to enable next‐generation 5G system networks to perform automated and intelligent analysis of their firmware images at massive scale, as well as the validation of applications and services. SANCUS also proposes a proactive risk assessment of network applications and services by means of maximising the overall system resilience in terms of security, privacy and reliability. This paper presents an overview of the SANCUS architecture in its current release as well as the pilots use cases that will be demonstrated at the end of the project and used for validating the concepts.