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  • SecondaryNucleation_Anwar_Feb2015

    Rights statement: This is the peer reviewed version of the following article:Anwar, J., Khan, S. and Lindfors, L. (2015), Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered. Angew. Chem. Int. Ed.. doi: 10.1002/anie.201501216 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201501216/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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  • SecondaryNucleation_SupplementaryInfo_Mar2015

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Secondary crystal nucleation: nuclei breeding factory uncovered

Research output: Contribution to journalJournal articlepeer-review

Published

Standard

Secondary crystal nucleation : nuclei breeding factory uncovered. / Anwar, Jamshed; Khan, Shahzeb; Lindfors, Lennart.

In: Angewandte Chemie International Edition, Vol. 54, No. 49, 01.12.2015, p. 14681-14684.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Anwar, J, Khan, S & Lindfors, L 2015, 'Secondary crystal nucleation: nuclei breeding factory uncovered', Angewandte Chemie International Edition, vol. 54, no. 49, pp. 14681-14684. https://doi.org/10.1002/anie.201501216

APA

Anwar, J., Khan, S., & Lindfors, L. (2015). Secondary crystal nucleation: nuclei breeding factory uncovered. Angewandte Chemie International Edition, 54(49), 14681-14684. https://doi.org/10.1002/anie.201501216

Vancouver

Anwar J, Khan S, Lindfors L. Secondary crystal nucleation: nuclei breeding factory uncovered. Angewandte Chemie International Edition. 2015 Dec 1;54(49):14681-14684. https://doi.org/10.1002/anie.201501216

Author

Anwar, Jamshed ; Khan, Shahzeb ; Lindfors, Lennart. / Secondary crystal nucleation : nuclei breeding factory uncovered. In: Angewandte Chemie International Edition. 2015 ; Vol. 54, No. 49. pp. 14681-14684.

Bibtex

@article{cf5a10eb4d72486487bf3ee3605736a8,
title = "Secondary crystal nucleation: nuclei breeding factory uncovered",
abstract = "Secondary nucleation, wherein crystal seeds are used to induce crystallization, is widely employed in industrial crystallizations. Despite its significance, our understanding of the process, particularly at the molecular level, remains rudimentary. An outstanding question is why do a few seeds give rise to a many-fold increase in new crystals? Using molecular simulation coupled with experiments we have uncovered the molecular processes that give rise to this autocatalytic behavior. The simulations reveal formation of molecular aggregates in solution, which on coming in contact with the surface of the seed undergo nucleation to form new crystallites. These crystallites are weakly bound to the crystal surface and can be readily sheared by fluid, making the seed surfaces available again to repeat the process. Further, the new crystallites on development can in turn serve as seeds. This mechanistic insight will enable better control in engineering crystalline products to design.",
keywords = "classical nucleation theory, crystal seeding , crystallization , molecular dynamics simulation, secondary nucleation",
author = "Jamshed Anwar and Shahzeb Khan and Lennart Lindfors",
note = "This is the peer reviewed version of the following article:Anwar, J., Khan, S. and Lindfors, L. (2015), Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered. Angew. Chem. Int. Ed.. doi: 10.1002/anie.201501216 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201501216/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.",
year = "2015",
month = dec,
day = "1",
doi = "10.1002/anie.201501216",
language = "English",
volume = "54",
pages = "14681--14684",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag",
number = "49",

}

RIS

TY - JOUR

T1 - Secondary crystal nucleation

T2 - nuclei breeding factory uncovered

AU - Anwar, Jamshed

AU - Khan, Shahzeb

AU - Lindfors, Lennart

N1 - This is the peer reviewed version of the following article:Anwar, J., Khan, S. and Lindfors, L. (2015), Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered. Angew. Chem. Int. Ed.. doi: 10.1002/anie.201501216 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201501216/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Secondary nucleation, wherein crystal seeds are used to induce crystallization, is widely employed in industrial crystallizations. Despite its significance, our understanding of the process, particularly at the molecular level, remains rudimentary. An outstanding question is why do a few seeds give rise to a many-fold increase in new crystals? Using molecular simulation coupled with experiments we have uncovered the molecular processes that give rise to this autocatalytic behavior. The simulations reveal formation of molecular aggregates in solution, which on coming in contact with the surface of the seed undergo nucleation to form new crystallites. These crystallites are weakly bound to the crystal surface and can be readily sheared by fluid, making the seed surfaces available again to repeat the process. Further, the new crystallites on development can in turn serve as seeds. This mechanistic insight will enable better control in engineering crystalline products to design.

AB - Secondary nucleation, wherein crystal seeds are used to induce crystallization, is widely employed in industrial crystallizations. Despite its significance, our understanding of the process, particularly at the molecular level, remains rudimentary. An outstanding question is why do a few seeds give rise to a many-fold increase in new crystals? Using molecular simulation coupled with experiments we have uncovered the molecular processes that give rise to this autocatalytic behavior. The simulations reveal formation of molecular aggregates in solution, which on coming in contact with the surface of the seed undergo nucleation to form new crystallites. These crystallites are weakly bound to the crystal surface and can be readily sheared by fluid, making the seed surfaces available again to repeat the process. Further, the new crystallites on development can in turn serve as seeds. This mechanistic insight will enable better control in engineering crystalline products to design.

KW - classical nucleation theory

KW - crystal seeding

KW - crystallization

KW - molecular dynamics simulation

KW - secondary nucleation

U2 - 10.1002/anie.201501216

DO - 10.1002/anie.201501216

M3 - Journal article

VL - 54

SP - 14681

EP - 14684

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 49

ER -