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Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances . / Lanza, Matteo; Acton, Joe; Sulzer, Philipp et al.
In: Journal of Mass Spectrometry, Vol. 50, No. 2, 02.2015, p. 427-431.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lanza, M, Acton, J, Sulzer, P, Breiev, K, Jürschik, S, Jordan, A, Hartungen, E, Hanel, G, Märk, L, Märk, T & Mayhew, CA 2015, 'Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances ', Journal of Mass Spectrometry, vol. 50, no. 2, pp. 427-431. https://doi.org/10.1002/jms.3514

APA

Lanza, M., Acton, J., Sulzer, P., Breiev, K., Jürschik, S., Jordan, A., Hartungen, E., Hanel, G., Märk, L., Märk, T., & Mayhew, C. A. (2015). Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances . Journal of Mass Spectrometry, 50(2), 427-431. https://doi.org/10.1002/jms.3514

Vancouver

Lanza M, Acton J, Sulzer P, Breiev K, Jürschik S, Jordan A et al. Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances . Journal of Mass Spectrometry. 2015 Feb;50(2):427-431. Epub 2015 Feb 2. doi: 10.1002/jms.3514

Author

Lanza, Matteo ; Acton, Joe ; Sulzer, Philipp et al. / Selective reagent ionisation-time of flight-mass spectrometry : a rapid technology for the novel analysis of blends of new psychoactive substances . In: Journal of Mass Spectrometry. 2015 ; Vol. 50, No. 2. pp. 427-431.

Bibtex

@article{e199b63895624efe86b38471bceffc65,
title = "Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances ",
abstract = "In this study we demonstrate the potential of selective reagent ionisation-time of flight-mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called {\textquoteleft}synthacaine{\textquoteright}, a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O+ result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O+ and NO+) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions. ",
keywords = "SRI-ToF-MS, PTR-MS, new psychoactive substances, drug detection, synthacaine",
author = "Matteo Lanza and Joe Acton and Philipp Sulzer and Kostiantyn Breiev and Simone J{\"u}rschik and Alfons Jordan and Eugen Hartungen and Gernot Hanel and Lukas M{\"a}rk and Tilmann M{\"a}rk and Mayhew, {Chris A.}",
year = "2015",
month = feb,
doi = "10.1002/jms.3514",
language = "English",
volume = "50",
pages = "427--431",
journal = "Journal of Mass Spectrometry",
issn = "1076-5174",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Selective reagent ionisation-time of flight-mass spectrometry

T2 - a rapid technology for the novel analysis of blends of new psychoactive substances

AU - Lanza, Matteo

AU - Acton, Joe

AU - Sulzer, Philipp

AU - Breiev, Kostiantyn

AU - Jürschik, Simone

AU - Jordan, Alfons

AU - Hartungen, Eugen

AU - Hanel, Gernot

AU - Märk, Lukas

AU - Märk, Tilmann

AU - Mayhew, Chris A.

PY - 2015/2

Y1 - 2015/2

N2 - In this study we demonstrate the potential of selective reagent ionisation-time of flight-mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called ‘synthacaine’, a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O+ result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O+ and NO+) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions.

AB - In this study we demonstrate the potential of selective reagent ionisation-time of flight-mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called ‘synthacaine’, a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O+ result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O+ and NO+) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions.

KW - SRI-ToF-MS

KW - PTR-MS

KW - new psychoactive substances

KW - drug detection

KW - synthacaine

U2 - 10.1002/jms.3514

DO - 10.1002/jms.3514

M3 - Journal article

VL - 50

SP - 427

EP - 431

JO - Journal of Mass Spectrometry

JF - Journal of Mass Spectrometry

SN - 1076-5174

IS - 2

ER -