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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa. / Haga, Ismar R.; Shih, Barbara B.; Tore, Gessica et al.
In: Viruses, Vol. 16, No. 4, 557, 03.04.2024.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Haga, IR, Shih, BB, Tore, G, Polo, N, Ribeca, P, Gombo-Ochir, D, Shura, G, Tserenchimed, T, Enkhbold, B, Purevtseren, D, Ulziibat, G, Damdinjav, B, Yimer, L, Bari, FD, Gizaw, D, Adedeji, AJ, Atai, RB, Adole, JA, Dogonyaro, BB, Kumarawadu, PL, Batten, C, Corla, A, Freimanis, GL, Tennakoon, C, Law, A, Lycett, S, Downing, T & Beard, PM 2024, 'Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa', Viruses, vol. 16, no. 4, 557. https://doi.org/10.3390/v16040557

APA

Haga, I. R., Shih, B. B., Tore, G., Polo, N., Ribeca, P., Gombo-Ochir, D., Shura, G., Tserenchimed, T., Enkhbold, B., Purevtseren, D., Ulziibat, G., Damdinjav, B., Yimer, L., Bari, F. D., Gizaw, D., Adedeji, A. J., Atai, R. B., Adole, J. A., Dogonyaro, B. B., ... Beard, P. M. (2024). Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa. Viruses, 16(4), Article 557. https://doi.org/10.3390/v16040557

Vancouver

Haga IR, Shih BB, Tore G, Polo N, Ribeca P, Gombo-Ochir D et al. Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa. Viruses. 2024 Apr 3;16(4):557. doi: 10.3390/v16040557

Author

Haga, Ismar R. ; Shih, Barbara B. ; Tore, Gessica et al. / Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa. In: Viruses. 2024 ; Vol. 16, No. 4.

Bibtex

@article{6360460867754386809167c284377c3e,
title = "Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa",
abstract = "Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have sequenced the whole genome of historical LSDV isolates from the Pirbright Institute virus archive, and field isolates from recent disease outbreaks in Sri Lanka, Mongolia, Nigeria and Ethiopia. These genome sequences were compared to published genomes and classified into different subgroups. Two subgroups contained vaccine or vaccine-like samples (“Neethling-like” clade 1.1 and “Kenya-like” subgroup, clade 1.2.2). One subgroup was associated with outbreaks of LSD in the Middle East/Europe (clade 1.2.1) and a previously unreported subgroup originated from cases of LSD in west and central Africa (clade 1.2.3). Isolates were also identified that contained a mix of genes from both wildtype and vaccine samples (vaccine-like recombinants, grouped in clade 2). Whole genome sequencing and analysis of LSDV strains isolated from different regions of Africa, Europe and Asia have provided new knowledge of the drivers of LSDV emergence, and will inform future disease control strategies.",
keywords = "Virology, Infectious Diseases",
author = "Haga, {Ismar R.} and Shih, {Barbara B.} and Gessica Tore and Noemi Polo and Paolo Ribeca and Delgerzul Gombo-Ochir and Gansukh Shura and Tsagaan Tserenchimed and Bazarragchaa Enkhbold and Dulam Purevtseren and Gerelmaa Ulziibat and Batchuluun Damdinjav and Lama Yimer and Bari, {Fufa D.} and Daniel Gizaw and Adedeji, {Adeyinka Jeremy} and Atai, {Rebecca Bitiyong} and Adole, {Jolly Amoche} and Dogonyaro, {Banenat Bajehson} and Kumarawadu, {Pradeep Lakpriya} and Carrie Batten and Amanda Corla and Freimanis, {Graham L.} and Chandana Tennakoon and Andy Law and Samantha Lycett and Tim Downing and Beard, {Philippa M.}",
year = "2024",
month = apr,
day = "3",
doi = "10.3390/v16040557",
language = "English",
volume = "16",
journal = "Viruses",
issn = "1999-4915",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa

AU - Haga, Ismar R.

AU - Shih, Barbara B.

AU - Tore, Gessica

AU - Polo, Noemi

AU - Ribeca, Paolo

AU - Gombo-Ochir, Delgerzul

AU - Shura, Gansukh

AU - Tserenchimed, Tsagaan

AU - Enkhbold, Bazarragchaa

AU - Purevtseren, Dulam

AU - Ulziibat, Gerelmaa

AU - Damdinjav, Batchuluun

AU - Yimer, Lama

AU - Bari, Fufa D.

AU - Gizaw, Daniel

AU - Adedeji, Adeyinka Jeremy

AU - Atai, Rebecca Bitiyong

AU - Adole, Jolly Amoche

AU - Dogonyaro, Banenat Bajehson

AU - Kumarawadu, Pradeep Lakpriya

AU - Batten, Carrie

AU - Corla, Amanda

AU - Freimanis, Graham L.

AU - Tennakoon, Chandana

AU - Law, Andy

AU - Lycett, Samantha

AU - Downing, Tim

AU - Beard, Philippa M.

PY - 2024/4/3

Y1 - 2024/4/3

N2 - Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have sequenced the whole genome of historical LSDV isolates from the Pirbright Institute virus archive, and field isolates from recent disease outbreaks in Sri Lanka, Mongolia, Nigeria and Ethiopia. These genome sequences were compared to published genomes and classified into different subgroups. Two subgroups contained vaccine or vaccine-like samples (“Neethling-like” clade 1.1 and “Kenya-like” subgroup, clade 1.2.2). One subgroup was associated with outbreaks of LSD in the Middle East/Europe (clade 1.2.1) and a previously unreported subgroup originated from cases of LSD in west and central Africa (clade 1.2.3). Isolates were also identified that contained a mix of genes from both wildtype and vaccine samples (vaccine-like recombinants, grouped in clade 2). Whole genome sequencing and analysis of LSDV strains isolated from different regions of Africa, Europe and Asia have provided new knowledge of the drivers of LSDV emergence, and will inform future disease control strategies.

AB - Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have sequenced the whole genome of historical LSDV isolates from the Pirbright Institute virus archive, and field isolates from recent disease outbreaks in Sri Lanka, Mongolia, Nigeria and Ethiopia. These genome sequences were compared to published genomes and classified into different subgroups. Two subgroups contained vaccine or vaccine-like samples (“Neethling-like” clade 1.1 and “Kenya-like” subgroup, clade 1.2.2). One subgroup was associated with outbreaks of LSD in the Middle East/Europe (clade 1.2.1) and a previously unreported subgroup originated from cases of LSD in west and central Africa (clade 1.2.3). Isolates were also identified that contained a mix of genes from both wildtype and vaccine samples (vaccine-like recombinants, grouped in clade 2). Whole genome sequencing and analysis of LSDV strains isolated from different regions of Africa, Europe and Asia have provided new knowledge of the drivers of LSDV emergence, and will inform future disease control strategies.

KW - Virology

KW - Infectious Diseases

U2 - 10.3390/v16040557

DO - 10.3390/v16040557

M3 - Journal article

VL - 16

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 4

M1 - 557

ER -