Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Short and medium chain length chlorinated paraffins in UK human milk fat
AU - Thomas, Gareth O.
AU - Farrar, David
AU - Braekvelt, Eric
AU - Stern, Gary
AU - Kalantzi, Olga L.
AU - Martin, Francis L.
AU - Jones, Kevin C.
PY - 2006/1
Y1 - 2006/1
N2 - Chlorinated paraffins (also called polychlorinated n-alkanes — PCAs) are a class of industrial chemicals comprising chlorinated straight chain hydrocarbons. They have a wide range of applications and are now found in a range of environmental compartments. We analysed a total of 25 human milk-fat samples, donated by 18 individuals from the urban London and more rural Lancaster areas in the UK, for short chain PCAs (C10–C13 sPCAs) and medium chain PCAs (C14–C17 mPCAs), using gas chromatography–ECNI high-resolution mass spectrometry. Our study confirms that trace quantities of PCAs can reach human milk-fat. sPCAs were detected in all but four samples, while mPCAs were detected in all samples. The median sPCA concentration was 180 ng/g fat (range of 49 to 820 ng/g fat — detected values only) and the median mPCA concentration was 21 ng/g fat (range of 6.2 to 320 ng/g fat). No differences were noted in ranges of observed values for either sPCAs or mPCAs between samples from London and Lancaster. Most samples also exhibited similar patterns of sPCAs and mPCAs. One sample exhibited a different pattern for sPCAs and mPCAs, an observation that may be related to differences in exposure or biological factors for this individual.
AB - Chlorinated paraffins (also called polychlorinated n-alkanes — PCAs) are a class of industrial chemicals comprising chlorinated straight chain hydrocarbons. They have a wide range of applications and are now found in a range of environmental compartments. We analysed a total of 25 human milk-fat samples, donated by 18 individuals from the urban London and more rural Lancaster areas in the UK, for short chain PCAs (C10–C13 sPCAs) and medium chain PCAs (C14–C17 mPCAs), using gas chromatography–ECNI high-resolution mass spectrometry. Our study confirms that trace quantities of PCAs can reach human milk-fat. sPCAs were detected in all but four samples, while mPCAs were detected in all samples. The median sPCA concentration was 180 ng/g fat (range of 49 to 820 ng/g fat — detected values only) and the median mPCA concentration was 21 ng/g fat (range of 6.2 to 320 ng/g fat). No differences were noted in ranges of observed values for either sPCAs or mPCAs between samples from London and Lancaster. Most samples also exhibited similar patterns of sPCAs and mPCAs. One sample exhibited a different pattern for sPCAs and mPCAs, an observation that may be related to differences in exposure or biological factors for this individual.
KW - Breast-milk
KW - Organochlorine
KW - SCCP
KW - MCCP
U2 - 10.1016/j.envint.2005.04.006
DO - 10.1016/j.envint.2005.04.006
M3 - Journal article
VL - 32
SP - 34
EP - 40
JO - Environment International
JF - Environment International
SN - 0160-4120
IS - 1
ER -