Home > Research > Publications & Outputs > Similarities in arterial arrival time prolongat...

Links

Text available via DOI:

View graph of relations

Similarities in arterial arrival time prolongation and posterior hypoperfusion in patients with idiopathic parkinson's disease and stroke

Research output: Contribution to Journal/MagazineJournal article

Published

Standard

Similarities in arterial arrival time prolongation and posterior hypoperfusion in patients with idiopathic parkinson's disease and stroke. / Al-Bachari, Sarah; Vidyasagar, Rishma; Silverdale, Monty et al.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 86, No. 11, 14.10.2015, p. 46.

Research output: Contribution to Journal/MagazineJournal article

Harvard

APA

Vancouver

Al-Bachari S, Vidyasagar R, Silverdale M, Emsley H, Parkes L. Similarities in arterial arrival time prolongation and posterior hypoperfusion in patients with idiopathic parkinson's disease and stroke. Journal of Neurology, Neurosurgery and Psychiatry. 2015 Oct 14;86(11):46. doi: 10.1136/jnnp-2015-312379.169

Author

Al-Bachari, Sarah ; Vidyasagar, Rishma ; Silverdale, Monty et al. / Similarities in arterial arrival time prolongation and posterior hypoperfusion in patients with idiopathic parkinson's disease and stroke. In: Journal of Neurology, Neurosurgery and Psychiatry. 2015 ; Vol. 86, No. 11. pp. 46.

Bibtex

@article{2d6b15b159554f16af98037ca5216c50,
title = "Similarities in arterial arrival time prolongation and posterior hypoperfusion in patients with idiopathic parkinson's disease and stroke",
abstract = "The relevance of impaired neurovascular function in idiopathic Parkinson's disease (IPD) is unknown. Furthermore, it is unknown whether any such changes might contribute to, or be the effect of, neurodegeneration, or potentially reflect comorbid cerebrovascular disease (CVD). MRI arterial spin labelling (ASL) is a suitable, non-invasive tool for quantifying cerebral haemodynamics including measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). Prolonged AAT has been attributed to increased collateral circulation, chronic vasodilatation and/or increased tortuosity of vessels.12 subjects with CVD (mean age 68.9±7.8), 19 tremor dominant (TD) IPD subjects (mean age 67.2±0.6), 17 postural instability and gait dominant (PIGD) IPD subjects (mean age 70.7±6.6) and 23 control subjects (mean age 65.1±5.7) completed a 3T MRI scanning protocol, including ASL. CVD subjects had significantly more cerebrovascular risk factors than the other groups. A significant widespread increase in baseline AAT was seen in IPD (both TD and PIGD) and CVD groups when compared to controls. Voxel-based analysis of CBF revealed significant focal hypoperfusion (predominantly posteriorly) in the TD, PIGD and the CVD groups when compared to controls.These novel findings suggesting similar alterations in cerebral haemodynamics in IPD and CVD groups merit further study.",
author = "Sarah Al-Bachari and Rishma Vidyasagar and Monty Silverdale and Hedley Emsley and Laura Parkes",
year = "2015",
month = oct,
day = "14",
doi = "10.1136/jnnp-2015-312379.169",
language = "English",
volume = "86",
pages = "46",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Similarities in arterial arrival time prolongation and posterior hypoperfusion in patients with idiopathic parkinson's disease and stroke

AU - Al-Bachari, Sarah

AU - Vidyasagar, Rishma

AU - Silverdale, Monty

AU - Emsley, Hedley

AU - Parkes, Laura

PY - 2015/10/14

Y1 - 2015/10/14

N2 - The relevance of impaired neurovascular function in idiopathic Parkinson's disease (IPD) is unknown. Furthermore, it is unknown whether any such changes might contribute to, or be the effect of, neurodegeneration, or potentially reflect comorbid cerebrovascular disease (CVD). MRI arterial spin labelling (ASL) is a suitable, non-invasive tool for quantifying cerebral haemodynamics including measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). Prolonged AAT has been attributed to increased collateral circulation, chronic vasodilatation and/or increased tortuosity of vessels.12 subjects with CVD (mean age 68.9±7.8), 19 tremor dominant (TD) IPD subjects (mean age 67.2±0.6), 17 postural instability and gait dominant (PIGD) IPD subjects (mean age 70.7±6.6) and 23 control subjects (mean age 65.1±5.7) completed a 3T MRI scanning protocol, including ASL. CVD subjects had significantly more cerebrovascular risk factors than the other groups. A significant widespread increase in baseline AAT was seen in IPD (both TD and PIGD) and CVD groups when compared to controls. Voxel-based analysis of CBF revealed significant focal hypoperfusion (predominantly posteriorly) in the TD, PIGD and the CVD groups when compared to controls.These novel findings suggesting similar alterations in cerebral haemodynamics in IPD and CVD groups merit further study.

AB - The relevance of impaired neurovascular function in idiopathic Parkinson's disease (IPD) is unknown. Furthermore, it is unknown whether any such changes might contribute to, or be the effect of, neurodegeneration, or potentially reflect comorbid cerebrovascular disease (CVD). MRI arterial spin labelling (ASL) is a suitable, non-invasive tool for quantifying cerebral haemodynamics including measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). Prolonged AAT has been attributed to increased collateral circulation, chronic vasodilatation and/or increased tortuosity of vessels.12 subjects with CVD (mean age 68.9±7.8), 19 tremor dominant (TD) IPD subjects (mean age 67.2±0.6), 17 postural instability and gait dominant (PIGD) IPD subjects (mean age 70.7±6.6) and 23 control subjects (mean age 65.1±5.7) completed a 3T MRI scanning protocol, including ASL. CVD subjects had significantly more cerebrovascular risk factors than the other groups. A significant widespread increase in baseline AAT was seen in IPD (both TD and PIGD) and CVD groups when compared to controls. Voxel-based analysis of CBF revealed significant focal hypoperfusion (predominantly posteriorly) in the TD, PIGD and the CVD groups when compared to controls.These novel findings suggesting similar alterations in cerebral haemodynamics in IPD and CVD groups merit further study.

U2 - 10.1136/jnnp-2015-312379.169

DO - 10.1136/jnnp-2015-312379.169

M3 - Journal article

VL - 86

SP - 46

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 11

ER -