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Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites. / Liu, Jiamin; Yang, Si; Tan, Yanni et al.
In: Biomaterials Advances, Vol. 141, 213123, 31.10.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Liu, J, Yang, S, Tan, Y, Liu, X, Tian, Y, Liang, L & Wu, H 2022, 'Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites.', Biomaterials Advances, vol. 141, 213123. https://doi.org/10.1016/j.bioadv.2022.213123

APA

Liu, J., Yang, S., Tan, Y., Liu, X., Tian, Y., Liang, L., & Wu, H. (2022). Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites. Biomaterials Advances, 141, Article 213123. https://doi.org/10.1016/j.bioadv.2022.213123

Vancouver

Liu J, Yang S, Tan Y, Liu X, Tian Y, Liang L et al. Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites. Biomaterials Advances. 2022 Oct 31;141:213123. Epub 2022 Sept 15. doi: 10.1016/j.bioadv.2022.213123

Author

Liu, Jiamin ; Yang, Si ; Tan, Yanni et al. / Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites. In: Biomaterials Advances. 2022 ; Vol. 141.

Bibtex

@article{3179c8a5220a4b85ad1888d0f2051e2e,
title = "Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites.",
abstract = "Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering. However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications. In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag 2O nanocomposites was developed by the sol-gel method. The Mg 2+ released from MgO-Ag 2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point. The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels. Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate. In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells. In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag 2O content. ",
keywords = "MgO-Ag(2)O nanocomposites, Osteogenesis, Anti-bacteria, Mechanical properties, Double-network hydrogel, Self-recovery",
author = "Jiamin Liu and Si Yang and Yanni Tan and Xiangyan Liu and Yingtao Tian and Luxin Liang and Hong Wu",
year = "2022",
month = oct,
day = "31",
doi = "10.1016/j.bioadv.2022.213123",
language = "English",
volume = "141",
journal = "Biomaterials Advances",
issn = "2772-9508",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Simultaneously stimulated osteogenesis and anti-bacteria of physically cross-linked double-network hydrogel loaded with MgO-Ag 2O nanocomposites.

AU - Liu, Jiamin

AU - Yang, Si

AU - Tan, Yanni

AU - Liu, Xiangyan

AU - Tian, Yingtao

AU - Liang, Luxin

AU - Wu, Hong

PY - 2022/10/31

Y1 - 2022/10/31

N2 - Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering. However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications. In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag 2O nanocomposites was developed by the sol-gel method. The Mg 2+ released from MgO-Ag 2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point. The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels. Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate. In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells. In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag 2O content.

AB - Hydrogels, with a three-dimensional network of water-soluble polymer and water, could simulate the critical properties of extracellular matrix, which has been widely used in bone tissue engineering. However, most of conventional hydrogels for bone regeneration are fragile and have poor osteogenic activity, which restricts their applications. In this work, a novel nanoparticle-hydrogel composite consisting of physically cross-linked double-network loaded with MgO-Ag 2O nanocomposites was developed by the sol-gel method. The Mg 2+ released from MgO-Ag 2O nanocomposites was used as an ionic cross-linking site of sodium alginate (SA), while the hydrophobic micelles in the polyacrylamide (PAAM) network is acted as another crosslinking point. The results indicated that the novel nanoparticle-hydrogel composites had good self-recovery ability and excellent mechanical properties compared with the conventional sodium alginate (SA)/polyacrylamide (PAAM) hydrogels. Additionally, it showed a slow release of Mg and Ag ions due to the dual function of the embedding effect of hydrogels and the increasing pH of the solution induced by the hydrolysis of sodium alginate. In terms of in vitro tests, the nanoparticle-hydrogel composites showed significantly stimulatory effects on the proliferation and differentiation of SaOS-2 cells. In addition, the antibacterial effects of the nanoparticle-hydrogel composites were gradually enhanced with the increase of MgO-Ag 2O content.

KW - MgO-Ag(2)O nanocomposites

KW - Osteogenesis

KW - Anti-bacteria

KW - Mechanical properties

KW - Double-network hydrogel

KW - Self-recovery

U2 - 10.1016/j.bioadv.2022.213123

DO - 10.1016/j.bioadv.2022.213123

M3 - Journal article

C2 - 36137446

VL - 141

JO - Biomaterials Advances

JF - Biomaterials Advances

SN - 2772-9508

M1 - 213123

ER -