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Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction. / Maddocks, Joe; Mahesh, Mohan; Sampani, Stavroula I. et al.
In: Royal Society Open Science, Vol. 12, No. 3, 241537, 31.03.2025.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Maddocks, J, Mahesh, M, Sampani, SI, Dixon, AC, Nielsen, CD-T, Kumar, P, Akien, GR, Spencer, J, Abdul-Sada, A, Turner, JFC, Spivey, AC & Kostakis, GE 2025, 'Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction', Royal Society Open Science, vol. 12, no. 3, 241537. https://doi.org/10.1098/rsos.241537

APA

Maddocks, J., Mahesh, M., Sampani, S. I., Dixon, A. C., Nielsen, C. D.-T., Kumar, P., Akien, G. R., Spencer, J., Abdul-Sada, A., Turner, J. F. C., Spivey, A. C., & Kostakis, G. E. (2025). Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction. Royal Society Open Science, 12(3), Article 241537. https://doi.org/10.1098/rsos.241537

Vancouver

Maddocks J, Mahesh M, Sampani SI, Dixon AC, Nielsen CDT, Kumar P et al. Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction. Royal Society Open Science. 2025 Mar 31;12(3):241537. Epub 2025 Mar 27. doi: 10.1098/rsos.241537

Author

Maddocks, Joe ; Mahesh, Mohan ; Sampani, Stavroula I. et al. / Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction. In: Royal Society Open Science. 2025 ; Vol. 12, No. 3.

Bibtex

@article{89e7beae32bd46259ce4e0d1a259a52e,
title = "Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction",
abstract = "We report a family of propeller-shaped polynuclear metal complexes whose overall chirality is dictated by a single stereogenic centre within their component amino alcohol-ligand. These topologically intriguing complexes are readily prepared in enantiomerically pure form and are shown here to catalyse the conjugate addition of barbituric acids and their derivatives to nitroalkenes, with a catalyst loading of 1 mol%. Although only low levels of enantioinduction are observed, control experiments indicate that the enantioselectivity is dictated by the overall topology of the complex and not governed by binding to the tetrametallic entity, heralding a potentially new mode of catalysis.",
keywords = "enantioselective induction, Michael addition reaction, propeller-shaped complexes",
author = "Joe Maddocks and Mohan Mahesh and Sampani, {Stavroula I.} and Dixon, {Alexander C.} and Nielsen, {Christian D.-T.} and Prashant Kumar and Akien, {Geoffrey R.} and John Spencer and Alaa Abdul-Sada and Turner, {John F. C.} and Spivey, {Alan C.} and Kostakis, {George E.}",
year = "2025",
month = mar,
day = "31",
doi = "10.1098/rsos.241537",
language = "English",
volume = "12",
journal = "Royal Society Open Science",
issn = "2054-5703",
publisher = "The Royal Society",
number = "3",

}

RIS

TY - JOUR

T1 - Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction

AU - Maddocks, Joe

AU - Mahesh, Mohan

AU - Sampani, Stavroula I.

AU - Dixon, Alexander C.

AU - Nielsen, Christian D.-T.

AU - Kumar, Prashant

AU - Akien, Geoffrey R.

AU - Spencer, John

AU - Abdul-Sada, Alaa

AU - Turner, John F. C.

AU - Spivey, Alan C.

AU - Kostakis, George E.

PY - 2025/3/31

Y1 - 2025/3/31

N2 - We report a family of propeller-shaped polynuclear metal complexes whose overall chirality is dictated by a single stereogenic centre within their component amino alcohol-ligand. These topologically intriguing complexes are readily prepared in enantiomerically pure form and are shown here to catalyse the conjugate addition of barbituric acids and their derivatives to nitroalkenes, with a catalyst loading of 1 mol%. Although only low levels of enantioinduction are observed, control experiments indicate that the enantioselectivity is dictated by the overall topology of the complex and not governed by binding to the tetrametallic entity, heralding a potentially new mode of catalysis.

AB - We report a family of propeller-shaped polynuclear metal complexes whose overall chirality is dictated by a single stereogenic centre within their component amino alcohol-ligand. These topologically intriguing complexes are readily prepared in enantiomerically pure form and are shown here to catalyse the conjugate addition of barbituric acids and their derivatives to nitroalkenes, with a catalyst loading of 1 mol%. Although only low levels of enantioinduction are observed, control experiments indicate that the enantioselectivity is dictated by the overall topology of the complex and not governed by binding to the tetrametallic entity, heralding a potentially new mode of catalysis.

KW - enantioselective induction

KW - Michael addition reaction

KW - propeller-shaped complexes

U2 - 10.1098/rsos.241537

DO - 10.1098/rsos.241537

M3 - Journal article

VL - 12

JO - Royal Society Open Science

JF - Royal Society Open Science

SN - 2054-5703

IS - 3

M1 - 241537

ER -