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Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue. / Oh, Jun Seok; Szili, Endre J.; Ito, Satsuki et al.
In: Plasma Medicine, Vol. 5, No. 2-4, 01.01.2015, p. 125-143.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Oh, JS, Szili, EJ, Ito, S, Hong, SH, Gaur, N, Furuta, H, Short, RD & Hatta, A 2015, 'Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue', Plasma Medicine, vol. 5, no. 2-4, pp. 125-143. https://doi.org/10.1615/PlasmaMed.2016015740

APA

Oh, J. S., Szili, E. J., Ito, S., Hong, S. H., Gaur, N., Furuta, H., Short, R. D., & Hatta, A. (2015). Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue. Plasma Medicine, 5(2-4), 125-143. https://doi.org/10.1615/PlasmaMed.2016015740

Vancouver

Oh JS, Szili EJ, Ito S, Hong SH, Gaur N, Furuta H et al. Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue. Plasma Medicine. 2015 Jan 1;5(2-4):125-143. doi: 10.1615/PlasmaMed.2016015740

Author

Oh, Jun Seok ; Szili, Endre J. ; Ito, Satsuki et al. / Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue. In: Plasma Medicine. 2015 ; Vol. 5, No. 2-4. pp. 125-143.

Bibtex

@article{59c6b6e770a049659ccfd1d2d1ab03ca,
title = "Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue",
abstract = "The helium (He) atmospheric-pressure plasma jet (APPJ) delivery of reactive oxygen and nitrogen species (RONS) and molecular oxygen (O2) in deionized (DI) water was monitored in real time using in situ UV absorption spectroscopy. The He APPJ was used to treat DI water directly and through an agarose target as a surrogate for tissue (e.g., a skin barrier). For direct treatment, the RONS were generated immediately in the DI water, and the concentration of RONS continued to increase during the He APPJ treatment. But there was only a very minor increase in the total RONS concentration detected after the plasma and gas flow were switched off. The agarose target delayed the generation of RONS into the DI water, but the total RONS concentration continued to increase long after (25 min) the plasma and gas flow were switched off. Direct treatment deoxygenated the DI water, whereas treatment through agarose resulted in oxygenation of the DI water. A dynamic change in the ratio of H2O2, NO2 -, NO3 -, and O2 was detected in the DI water during He APPJ treatment and 25 min after the He and gas flow were switched off for both direct and through-agarose treatment. These results have implications for the plasma treatment of real tissue where the dynamic changes in the RONS and O2 concentrations within the tissue and tissue fluid could affect cellular and physiological processes.",
keywords = "Agarose target, Deoxygenation, In situ UV absorption spectroscopy, Oxygenation, RONS transport",
author = "Oh, {Jun Seok} and Szili, {Endre J.} and Satsuki Ito and Hong, {Sung Ha} and Nishtha Gaur and Hiroshi Furuta and Short, {Robert D.} and Akimitsu Hatta",
year = "2015",
month = jan,
day = "1",
doi = "10.1615/PlasmaMed.2016015740",
language = "English",
volume = "5",
pages = "125--143",
journal = "Plasma Medicine",
issn = "1947-5764",
publisher = "Begell House Inc.",
number = "2-4",

}

RIS

TY - JOUR

T1 - Slow molecular transport of plasma-generated reactive oxygen and nitrogen species and O2 through agarose as a surrogate for tissue

AU - Oh, Jun Seok

AU - Szili, Endre J.

AU - Ito, Satsuki

AU - Hong, Sung Ha

AU - Gaur, Nishtha

AU - Furuta, Hiroshi

AU - Short, Robert D.

AU - Hatta, Akimitsu

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The helium (He) atmospheric-pressure plasma jet (APPJ) delivery of reactive oxygen and nitrogen species (RONS) and molecular oxygen (O2) in deionized (DI) water was monitored in real time using in situ UV absorption spectroscopy. The He APPJ was used to treat DI water directly and through an agarose target as a surrogate for tissue (e.g., a skin barrier). For direct treatment, the RONS were generated immediately in the DI water, and the concentration of RONS continued to increase during the He APPJ treatment. But there was only a very minor increase in the total RONS concentration detected after the plasma and gas flow were switched off. The agarose target delayed the generation of RONS into the DI water, but the total RONS concentration continued to increase long after (25 min) the plasma and gas flow were switched off. Direct treatment deoxygenated the DI water, whereas treatment through agarose resulted in oxygenation of the DI water. A dynamic change in the ratio of H2O2, NO2 -, NO3 -, and O2 was detected in the DI water during He APPJ treatment and 25 min after the He and gas flow were switched off for both direct and through-agarose treatment. These results have implications for the plasma treatment of real tissue where the dynamic changes in the RONS and O2 concentrations within the tissue and tissue fluid could affect cellular and physiological processes.

AB - The helium (He) atmospheric-pressure plasma jet (APPJ) delivery of reactive oxygen and nitrogen species (RONS) and molecular oxygen (O2) in deionized (DI) water was monitored in real time using in situ UV absorption spectroscopy. The He APPJ was used to treat DI water directly and through an agarose target as a surrogate for tissue (e.g., a skin barrier). For direct treatment, the RONS were generated immediately in the DI water, and the concentration of RONS continued to increase during the He APPJ treatment. But there was only a very minor increase in the total RONS concentration detected after the plasma and gas flow were switched off. The agarose target delayed the generation of RONS into the DI water, but the total RONS concentration continued to increase long after (25 min) the plasma and gas flow were switched off. Direct treatment deoxygenated the DI water, whereas treatment through agarose resulted in oxygenation of the DI water. A dynamic change in the ratio of H2O2, NO2 -, NO3 -, and O2 was detected in the DI water during He APPJ treatment and 25 min after the He and gas flow were switched off for both direct and through-agarose treatment. These results have implications for the plasma treatment of real tissue where the dynamic changes in the RONS and O2 concentrations within the tissue and tissue fluid could affect cellular and physiological processes.

KW - Agarose target

KW - Deoxygenation

KW - In situ UV absorption spectroscopy

KW - Oxygenation

KW - RONS transport

U2 - 10.1615/PlasmaMed.2016015740

DO - 10.1615/PlasmaMed.2016015740

M3 - Journal article

AN - SCOPUS:84991220713

VL - 5

SP - 125

EP - 143

JO - Plasma Medicine

JF - Plasma Medicine

SN - 1947-5764

IS - 2-4

ER -