TY - JOUR

T1 - Small regions of preferential codon usage and their effect on overall codon bias

T2 - the case of the plp gene

AU - Gatherer, Derek

AU - McEwan, Neil R.

PY - 1997/9

Y1 - 1997/9

N2 - Preferential codon usage within synonymous groups (codon bias), is hypothesised to be a consequence of either mutational pressure or translational selection. This paper examines PLP and DM-20, two transcripts differentially spliced from the pip gene, using a variety of previously described indices measuring codon bias as well as a novel index for quantifying the response to directional mutation pressure. The results demonstrate that small regions of extreme codon bias may have appreciable effects on the quantification of total bias, and that this effect may be either an increase or a decrease depending which index is used.

AB - Preferential codon usage within synonymous groups (codon bias), is hypothesised to be a consequence of either mutational pressure or translational selection. This paper examines PLP and DM-20, two transcripts differentially spliced from the pip gene, using a variety of previously described indices measuring codon bias as well as a novel index for quantifying the response to directional mutation pressure. The results demonstrate that small regions of extreme codon bias may have appreciable effects on the quantification of total bias, and that this effect may be either an increase or a decrease depending which index is used.

KW - MYELIN PROTEOLIPID PROTEIN

KW - TRANSLATIONAL SELECTION

KW - MESSENGER-RNA

KW - JIMPY MUTANT

KW - EXPRESSION

KW - MOUSE

M3 - Journal article

VL - 43

SP - 107

EP - 114

JO - Biochemistry and Molecular Biology International

JF - Biochemistry and Molecular Biology International

SN - 1039-9712

IS - 1

ER -