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Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia.

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Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia. / Ettinger, Ulrich; Kumari, Veena; Crawford, Trevor J.; Corr, Philip J.; Das, Mrigendra; Zachariah, Elizabeth; Hughes, Catherine; Sumich, Alex L.; Rabe-Hesketh, Sophia; Sharma, Tonmoy.

In: Journal of Psychiatric Research, Vol. 38, No. 2, 03.2004, p. 177-184.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ettinger, U, Kumari, V, Crawford, TJ, Corr, PJ, Das, M, Zachariah, E, Hughes, C, Sumich, AL, Rabe-Hesketh, S & Sharma, T 2004, 'Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia.', Journal of Psychiatric Research, vol. 38, no. 2, pp. 177-184. https://doi.org/10.1016/S0022-3956(03)00105-5

APA

Ettinger, U., Kumari, V., Crawford, T. J., Corr, P. J., Das, M., Zachariah, E., Hughes, C., Sumich, A. L., Rabe-Hesketh, S., & Sharma, T. (2004). Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia. Journal of Psychiatric Research, 38(2), 177-184. https://doi.org/10.1016/S0022-3956(03)00105-5

Vancouver

Ettinger U, Kumari V, Crawford TJ, Corr PJ, Das M, Zachariah E et al. Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia. Journal of Psychiatric Research. 2004 Mar;38(2):177-184. https://doi.org/10.1016/S0022-3956(03)00105-5

Author

Ettinger, Ulrich ; Kumari, Veena ; Crawford, Trevor J. ; Corr, Philip J. ; Das, Mrigendra ; Zachariah, Elizabeth ; Hughes, Catherine ; Sumich, Alex L. ; Rabe-Hesketh, Sophia ; Sharma, Tonmoy. / Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia. In: Journal of Psychiatric Research. 2004 ; Vol. 38, No. 2. pp. 177-184.

Bibtex

@article{aace64e0610c4a8f81bc5532f991081d,
title = "Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia.",
abstract = "Smooth pursuit eye movement (SPEM) and antisaccade deficits have been proposed as endophenotypes in the search for schizophrenia genes. We assessed these measures in 24 schizophrenia patients, 24 of their healthy siblings, and 24 healthy controls closely matched to the siblings. Between-group differences were assessed using a random effects regression model taking into account the relatedness between patients and siblings. Patients showed reduced SPEM gain, increased frequency of saccades during pursuit, increased antisaccade error rate, and reduced antisaccade gain compared to controls. Siblings performed intermediate, i.e. between patients and controls, on most measures, but were particularly characterised by reduced antisaccade gain. SPEM gain at one target velocity was significantly correlated between patients and siblings, highlighting the necessity of taking into account within-family correlations in the statistical analysis of between-group differences. It is concluded that subtle SPEM and antisaccade deficits are observed in clinically unaffected siblings of schizophrenia patients; these deficits may be useful markers of genetic liability to schizophrenia.",
keywords = "Schizophrenia, Endophenotype, Genetics, Smooth pursuit eye movements, Antisaccade, First-degree relatives",
author = "Ulrich Ettinger and Veena Kumari and Crawford, {Trevor J.} and Corr, {Philip J.} and Mrigendra Das and Elizabeth Zachariah and Catherine Hughes and Sumich, {Alex L.} and Sophia Rabe-Hesketh and Tonmoy Sharma",
year = "2004",
month = mar,
doi = "10.1016/S0022-3956(03)00105-5",
language = "English",
volume = "38",
pages = "177--184",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "2",

}

RIS

TY - JOUR

T1 - Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia.

AU - Ettinger, Ulrich

AU - Kumari, Veena

AU - Crawford, Trevor J.

AU - Corr, Philip J.

AU - Das, Mrigendra

AU - Zachariah, Elizabeth

AU - Hughes, Catherine

AU - Sumich, Alex L.

AU - Rabe-Hesketh, Sophia

AU - Sharma, Tonmoy

PY - 2004/3

Y1 - 2004/3

N2 - Smooth pursuit eye movement (SPEM) and antisaccade deficits have been proposed as endophenotypes in the search for schizophrenia genes. We assessed these measures in 24 schizophrenia patients, 24 of their healthy siblings, and 24 healthy controls closely matched to the siblings. Between-group differences were assessed using a random effects regression model taking into account the relatedness between patients and siblings. Patients showed reduced SPEM gain, increased frequency of saccades during pursuit, increased antisaccade error rate, and reduced antisaccade gain compared to controls. Siblings performed intermediate, i.e. between patients and controls, on most measures, but were particularly characterised by reduced antisaccade gain. SPEM gain at one target velocity was significantly correlated between patients and siblings, highlighting the necessity of taking into account within-family correlations in the statistical analysis of between-group differences. It is concluded that subtle SPEM and antisaccade deficits are observed in clinically unaffected siblings of schizophrenia patients; these deficits may be useful markers of genetic liability to schizophrenia.

AB - Smooth pursuit eye movement (SPEM) and antisaccade deficits have been proposed as endophenotypes in the search for schizophrenia genes. We assessed these measures in 24 schizophrenia patients, 24 of their healthy siblings, and 24 healthy controls closely matched to the siblings. Between-group differences were assessed using a random effects regression model taking into account the relatedness between patients and siblings. Patients showed reduced SPEM gain, increased frequency of saccades during pursuit, increased antisaccade error rate, and reduced antisaccade gain compared to controls. Siblings performed intermediate, i.e. between patients and controls, on most measures, but were particularly characterised by reduced antisaccade gain. SPEM gain at one target velocity was significantly correlated between patients and siblings, highlighting the necessity of taking into account within-family correlations in the statistical analysis of between-group differences. It is concluded that subtle SPEM and antisaccade deficits are observed in clinically unaffected siblings of schizophrenia patients; these deficits may be useful markers of genetic liability to schizophrenia.

KW - Schizophrenia

KW - Endophenotype

KW - Genetics

KW - Smooth pursuit eye movements

KW - Antisaccade

KW - First-degree relatives

U2 - 10.1016/S0022-3956(03)00105-5

DO - 10.1016/S0022-3956(03)00105-5

M3 - Journal article

VL - 38

SP - 177

EP - 184

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 2

ER -