Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Smooth pursuit and saccadic abnormalities in first-episode schizophrenia.
AU - Hutton, S.
AU - Crawford, Trevor J.
AU - Puri, B. K.
AU - Duncan, L.-J.
AU - Kennard, C.
AU - Barnes, T. R. E.
AU - Joyce, E. M.
N1 - http://journals.cambridge.org/action/displayJournal?jid=PSM The final, definitive version of this article has been published in the Journal, Psychological Medicine, 28 (3), pp 685-692 1998, © 1998 Cambridge University Press.
PY - 1998/5
Y1 - 1998/5
N2 - Background. Previous studies of oculomotor dysfunction in schizophrenia have tended to concentrate on abnormalities of smooth pursuit eye tracking in chronic medicated patients. We report the results of a study of smooth pursuit, re¯exive and antisaccade performance in drug naive and antipsychotic treated ®rst-episode schizophrenic patients. Methods. Smooth pursuit and saccadic eye movements were recorded in 36 ®rst-episode schizophrenic patients and 36 controls matched for age and estimated IQ. The schizophrenic patients were divided into drug-naive (N¯17) and antipsychotic treated groups (N¯19). Results. Smooth pursuit velocity gain was signi®cantly lower than controls only in the drug-naive patients. The treated patients did not differ signi®cantly from either the controls or the untreated group. In an antisaccade paradigm both treated and drug-naive schizophrenic patients demonstrated an increased number of errors, but only drug-naive patients also demonstrated an increased latency in initiating correct antisaccades. Conclusions. These impairments are unlikely to be due to a generalized de®cit in oculomotor function in the schizophrenic groups, as there were no differences between the groups in saccadic metrics on a re¯exive saccade task. The results show that both smooth pursuit and saccadic abnormalities are present at the onset of schizophrenia and are integral to the disorder.
AB - Background. Previous studies of oculomotor dysfunction in schizophrenia have tended to concentrate on abnormalities of smooth pursuit eye tracking in chronic medicated patients. We report the results of a study of smooth pursuit, re¯exive and antisaccade performance in drug naive and antipsychotic treated ®rst-episode schizophrenic patients. Methods. Smooth pursuit and saccadic eye movements were recorded in 36 ®rst-episode schizophrenic patients and 36 controls matched for age and estimated IQ. The schizophrenic patients were divided into drug-naive (N¯17) and antipsychotic treated groups (N¯19). Results. Smooth pursuit velocity gain was signi®cantly lower than controls only in the drug-naive patients. The treated patients did not differ signi®cantly from either the controls or the untreated group. In an antisaccade paradigm both treated and drug-naive schizophrenic patients demonstrated an increased number of errors, but only drug-naive patients also demonstrated an increased latency in initiating correct antisaccades. Conclusions. These impairments are unlikely to be due to a generalized de®cit in oculomotor function in the schizophrenic groups, as there were no differences between the groups in saccadic metrics on a re¯exive saccade task. The results show that both smooth pursuit and saccadic abnormalities are present at the onset of schizophrenia and are integral to the disorder.
U2 - 10.1017/S0033291798006722
DO - 10.1017/S0033291798006722
M3 - Journal article
VL - 28
SP - 685
EP - 692
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 3
ER -