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Social contacts and the locations in which they occur as risk factors for influenza infection

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Social contacts and the locations in which they occur as risk factors for influenza infection. / Kwok, Kin O.; Cowling, Benjamin J.; Wei, Vivian W. I.; Wu, Kendra M.; Read, Jonathan M.; Lessler, Justin; Cummings, Derek A.; Peiris, J. S. Malik; Riley, Steven.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 281, No. 1789, 20140709, 22.08.2014.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Kwok, KO, Cowling, BJ, Wei, VWI, Wu, KM, Read, JM, Lessler, J, Cummings, DA, Peiris, JSM & Riley, S 2014, 'Social contacts and the locations in which they occur as risk factors for influenza infection', Proceedings of the Royal Society B: Biological Sciences, vol. 281, no. 1789, 20140709. https://doi.org/10.1098/rspb.2014.0709

APA

Kwok, K. O., Cowling, B. J., Wei, V. W. I., Wu, K. M., Read, J. M., Lessler, J., Cummings, D. A., Peiris, J. S. M., & Riley, S. (2014). Social contacts and the locations in which they occur as risk factors for influenza infection. Proceedings of the Royal Society B: Biological Sciences, 281(1789), [20140709]. https://doi.org/10.1098/rspb.2014.0709

Vancouver

Kwok KO, Cowling BJ, Wei VWI, Wu KM, Read JM, Lessler J et al. Social contacts and the locations in which they occur as risk factors for influenza infection. Proceedings of the Royal Society B: Biological Sciences. 2014 Aug 22;281(1789). 20140709. https://doi.org/10.1098/rspb.2014.0709

Author

Kwok, Kin O. ; Cowling, Benjamin J. ; Wei, Vivian W. I. ; Wu, Kendra M. ; Read, Jonathan M. ; Lessler, Justin ; Cummings, Derek A. ; Peiris, J. S. Malik ; Riley, Steven. / Social contacts and the locations in which they occur as risk factors for influenza infection. In: Proceedings of the Royal Society B: Biological Sciences. 2014 ; Vol. 281, No. 1789.

Bibtex

@article{66b7c87127aa45758ac77430bdad285c,
title = "Social contacts and the locations in which they occur as risk factors for influenza infection",
abstract = "The interaction of human social behaviour and transmission is an intriguing aspect of the life cycle of respiratory viral infections. Although age-specific mixing patterns are often assumed to be the key drivers of the age-specific heterogeneity in transmission, the association between social contacts and biologically confirmed infection has not previously been tested at the individual level. We administered a questionnaire to participants in a longitudinal cohort survey of influenza in which infection was defined by longitudinal paired serology. Using a variety of statistical approaches, we found overwhelming support for the inclusion of individual age in addition to contact variables when explaining odds of infection: the best model not including age explained only 15.7% of the deviance, whereas the best model with age explained 23.6%. However, within age groups, we did observe an association between contacts, locations and infection: median numbers of contacts (or locations) reported by those infected were higher than those from the uninfected group in every age group other than the youngest. Further, we found some support for the retention of location and contact variables in addition to age in our regression models, with excess odds of infection of approximately 10% per additional 10 contacts or one location. These results suggest that, although the relationship between age and incidence of respiratory infection at the level of the individual is not driven by self-reported social contacts, risk within an age group may be.",
keywords = "pandemic, influenza, contact patterns, LOGISTIC-REGRESSION, MIXING PATTERNS, SPREAD, TRANSMISSION",
author = "Kwok, {Kin O.} and Cowling, {Benjamin J.} and Wei, {Vivian W. I.} and Wu, {Kendra M.} and Read, {Jonathan M.} and Justin Lessler and Cummings, {Derek A.} and Peiris, {J. S. Malik} and Steven Riley",
year = "2014",
month = aug,
day = "22",
doi = "10.1098/rspb.2014.0709",
language = "English",
volume = "281",
journal = "Proceedings of the Royal Society B: Biological Sciences",
issn = "0962-8452",
publisher = "Royal Society of Chemistry Publishing",
number = "1789",

}

RIS

TY - JOUR

T1 - Social contacts and the locations in which they occur as risk factors for influenza infection

AU - Kwok, Kin O.

AU - Cowling, Benjamin J.

AU - Wei, Vivian W. I.

AU - Wu, Kendra M.

AU - Read, Jonathan M.

AU - Lessler, Justin

AU - Cummings, Derek A.

AU - Peiris, J. S. Malik

AU - Riley, Steven

PY - 2014/8/22

Y1 - 2014/8/22

N2 - The interaction of human social behaviour and transmission is an intriguing aspect of the life cycle of respiratory viral infections. Although age-specific mixing patterns are often assumed to be the key drivers of the age-specific heterogeneity in transmission, the association between social contacts and biologically confirmed infection has not previously been tested at the individual level. We administered a questionnaire to participants in a longitudinal cohort survey of influenza in which infection was defined by longitudinal paired serology. Using a variety of statistical approaches, we found overwhelming support for the inclusion of individual age in addition to contact variables when explaining odds of infection: the best model not including age explained only 15.7% of the deviance, whereas the best model with age explained 23.6%. However, within age groups, we did observe an association between contacts, locations and infection: median numbers of contacts (or locations) reported by those infected were higher than those from the uninfected group in every age group other than the youngest. Further, we found some support for the retention of location and contact variables in addition to age in our regression models, with excess odds of infection of approximately 10% per additional 10 contacts or one location. These results suggest that, although the relationship between age and incidence of respiratory infection at the level of the individual is not driven by self-reported social contacts, risk within an age group may be.

AB - The interaction of human social behaviour and transmission is an intriguing aspect of the life cycle of respiratory viral infections. Although age-specific mixing patterns are often assumed to be the key drivers of the age-specific heterogeneity in transmission, the association between social contacts and biologically confirmed infection has not previously been tested at the individual level. We administered a questionnaire to participants in a longitudinal cohort survey of influenza in which infection was defined by longitudinal paired serology. Using a variety of statistical approaches, we found overwhelming support for the inclusion of individual age in addition to contact variables when explaining odds of infection: the best model not including age explained only 15.7% of the deviance, whereas the best model with age explained 23.6%. However, within age groups, we did observe an association between contacts, locations and infection: median numbers of contacts (or locations) reported by those infected were higher than those from the uninfected group in every age group other than the youngest. Further, we found some support for the retention of location and contact variables in addition to age in our regression models, with excess odds of infection of approximately 10% per additional 10 contacts or one location. These results suggest that, although the relationship between age and incidence of respiratory infection at the level of the individual is not driven by self-reported social contacts, risk within an age group may be.

KW - pandemic

KW - influenza

KW - contact patterns

KW - LOGISTIC-REGRESSION

KW - MIXING PATTERNS

KW - SPREAD

KW - TRANSMISSION

U2 - 10.1098/rspb.2014.0709

DO - 10.1098/rspb.2014.0709

M3 - Journal article

VL - 281

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

SN - 0962-8452

IS - 1789

M1 - 20140709

ER -