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Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans

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Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans. / Laranjeiro, Ricardo; Harinath, Girish; Pollard, Amelia K.; Gaffney, Christopher; Deane, Colleen; Vanapalli, Siva; Etheridge, Timothy; Szewczyk, Nathaniel J; Driscoll, Monica.

In: iScience, Vol. 24, No. 2, 102105, 19.02.2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Laranjeiro, R, Harinath, G, Pollard, AK, Gaffney, C, Deane, C, Vanapalli, S, Etheridge, T, Szewczyk, NJ & Driscoll, M 2021, 'Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans', iScience, vol. 24, no. 2, 102105. https://doi.org/10.1016/j.isci.2021.102105

APA

Laranjeiro, R., Harinath, G., Pollard, A. K., Gaffney, C., Deane, C., Vanapalli, S., Etheridge, T., Szewczyk, N. J., & Driscoll, M. (2021). Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans. iScience, 24(2), [102105]. https://doi.org/10.1016/j.isci.2021.102105

Vancouver

Author

Laranjeiro, Ricardo ; Harinath, Girish ; Pollard, Amelia K. ; Gaffney, Christopher ; Deane, Colleen ; Vanapalli, Siva ; Etheridge, Timothy ; Szewczyk, Nathaniel J ; Driscoll, Monica. / Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans. In: iScience. 2021 ; Vol. 24, No. 2.

Bibtex

@article{eb3485cf352e48fcbd8da6598f8522ca,
title = "Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans",
abstract = "and private companies. However, spaceflight poses risks to human health and the effects on the nervous system have to be better characterized. Here, we exploited the unique experimental advantages of the nematode Caenorhabditis elegans to explore how spaceflight affects adult neurons in vivo. We found that animals that lived 5 days of adulthood on the International Space Station exhibited hyperbranching in PVD and touch receptor neurons. We also found that, in the presence of a neuronal proteotoxic stress, spaceflight promotes a remarkable accumulation of neuronal-derived waste in the surrounding tissues, suggesting an impaired transcellular degradation of debris released from neurons. Our data reveal that spaceflight can significantly affect adult neuronal morphology and clearance of neuronal trash, highlighting the need to carefully assess the risks of long-duration spaceflight on the nervous system and to develop adequate countermeasures for safe space exploration.",
author = "Ricardo Laranjeiro and Girish Harinath and Pollard, {Amelia K.} and Christopher Gaffney and Colleen Deane and Siva Vanapalli and Timothy Etheridge and Szewczyk, {Nathaniel J} and Monica Driscoll",
year = "2021",
month = feb,
day = "19",
doi = "10.1016/j.isci.2021.102105",
language = "English",
volume = "24",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans

AU - Laranjeiro, Ricardo

AU - Harinath, Girish

AU - Pollard, Amelia K.

AU - Gaffney, Christopher

AU - Deane, Colleen

AU - Vanapalli, Siva

AU - Etheridge, Timothy

AU - Szewczyk, Nathaniel J

AU - Driscoll, Monica

PY - 2021/2/19

Y1 - 2021/2/19

N2 - and private companies. However, spaceflight poses risks to human health and the effects on the nervous system have to be better characterized. Here, we exploited the unique experimental advantages of the nematode Caenorhabditis elegans to explore how spaceflight affects adult neurons in vivo. We found that animals that lived 5 days of adulthood on the International Space Station exhibited hyperbranching in PVD and touch receptor neurons. We also found that, in the presence of a neuronal proteotoxic stress, spaceflight promotes a remarkable accumulation of neuronal-derived waste in the surrounding tissues, suggesting an impaired transcellular degradation of debris released from neurons. Our data reveal that spaceflight can significantly affect adult neuronal morphology and clearance of neuronal trash, highlighting the need to carefully assess the risks of long-duration spaceflight on the nervous system and to develop adequate countermeasures for safe space exploration.

AB - and private companies. However, spaceflight poses risks to human health and the effects on the nervous system have to be better characterized. Here, we exploited the unique experimental advantages of the nematode Caenorhabditis elegans to explore how spaceflight affects adult neurons in vivo. We found that animals that lived 5 days of adulthood on the International Space Station exhibited hyperbranching in PVD and touch receptor neurons. We also found that, in the presence of a neuronal proteotoxic stress, spaceflight promotes a remarkable accumulation of neuronal-derived waste in the surrounding tissues, suggesting an impaired transcellular degradation of debris released from neurons. Our data reveal that spaceflight can significantly affect adult neuronal morphology and clearance of neuronal trash, highlighting the need to carefully assess the risks of long-duration spaceflight on the nervous system and to develop adequate countermeasures for safe space exploration.

U2 - 10.1016/j.isci.2021.102105

DO - 10.1016/j.isci.2021.102105

M3 - Journal article

VL - 24

JO - iScience

JF - iScience

SN - 2589-0042

IS - 2

M1 - 102105

ER -