This Special Issue focuses on proposing and analyzing systemic interdisciplinary approaches to support collaborative strategies and agreed-upon global sustainability policies toward addressing the challenges that lie ahead for our planet’s future. The contributions target applications in system dynamics, systems thinking, discrete event simulation, agent-based modelling, and hybrid approaches and provide valuable qualitative and quantitative insights to guide the collaborative efforts of governments, institutions, organizations in general, and even the financial sector toward the next Conference of Parties (COP28).